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Article
Effect of 21-Day Dry Immersion on Expression of Inborn Immunity Genes Associated with the Toll-Like Receptors of Signaling Pathways
Expression of inborn immunity genes was studied in 10 essentially healthy male subjects aged 24 to 32 years in a 21-day dry immersion (DI) experiment without countermeasures. To evaluate the humoral immunity f...
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Article
Immunological Aspects of Reactivation of Latent Infections in Space Flight and Antarctica
The complex of space flight (SF) factors can have a negative impact on the human organism, including innate and adaptive immunity. One of the negative effects of impaired functional activity of the immune syst...
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Article
State of the Human Innate Immunity Cell Component during 120-Day Isolation in a Pressurized Module
Innate immunity was investigated in six volunteers aged 28 to 44 years participating in the experiment with 120-day isolation in a controlled environment. Peripheral blood samples collected during isolation we...
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Article
Correlations between Biochemical and Immunological Parameters in Volunteers under Conditions of 21-Day “Dry” Immersion
The results of studying the correlations between biochemical and immunological parameters in volunteers under conditions of 21-day “dry” immersion are presented. It is shown that, in comparison with the baseli...
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Article
Van der Waals Heteroepitaxial Growth of Layered SnSe \({}_{\mathbf{2}}\) on Surfaces Si(111) and Bi \({}_{\mathbf{2}}\) Se \({}_{\mathbf{3}}\) (0001)
Layered SnSe \({}_{2}\) films of nearly 50 and 30 nm in thickness were grown on Si(111) and Bi ...
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Article
Open AccessEndothelial dysfunction markers and immune response indices in cosmonauts’ blood after long-duration space flights
Space flight factors are known to cause a malfunction in the human immune system and lead to damage to blood vessels. The hemostatic function of endothelium during space missions and its interaction with human...
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Article
Open AccessThe impact of short-term confinement on human innate immunity
During space missions cosmonauts are exposed to a myriad of distinct stressors such as radiation, overloads, weightlessness, radiation, isolation in artificial environmental conditions, which causes changes in...
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Article
21-Day Dry Immersion: Schedule of Investigations and Major Results
The paper describes the main stages of the protocol and results of a unique 21-day experiment undertaken at the Russian Federation State Research Center Institute of Biomedical Problems of the Russian Academy ...
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Article
In Situ Reflection Electron Microscopy for the Analysis of Silicon Surface Processes: Sublimation, Electromigration, and Adsorption of Impurity Atoms
The results of recent studies of the structural morphological transformations of Si(111) and Si(100) surfaces using in situ ultrahigh-vacuum reflection electron microscopy (UHV REM) are presented. It is establ...
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Article
Effect of 21-day Dry Immersion on the Production of Cytokines Involved in the Regulation of Bone Metabolism by T Cells
Activated T cells from peripheral blood of six volunteers, participants of the experiment with 21-day dry immersion (DI), were analyzed. The results of analysis of the synthesis of cytokines affecting the meta...
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Article
Etching Kinetics of Si(111) Surface by Selenium Molecular Beam
Using in situ ultrahigh vacuum reflection electron microscopy, three modes of the etching kinetics of the Si(111) surface with a selenium molecular beam are revealed. In the low temperature region ( ...
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Article
Cytokine Profile in Volunteers during a 21-Day Dry Immersion without Countermeasures
We studied the cytokine profile in ten healthy volunteers participating in the experiment with a 21-day-long dry immersion (DI). The results of these studies revealed pronounced individual differences in the i...
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Article
Metabolic Responses of the Female Body during a Short-term Isolation in Hermetic Environment
The program of the Moon-2015 eight-day experiment simulating a lunar flyby to study the mechanisms controlling the female body adaptation to the conditions of isolation in a hermetically sealed environment (IH...
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Article
Cell Immunity Indices in Crew Members of the Moon-2015 Project
Cell immunity indices were studied in 6 female participants in the Moon-2015 project at the age of 25 to 34 years. Peripheral blood was analyzed for lymphocyte subtypes CD3+, CD3+CD4+, CD3+CD8+, CD19+, and CD3–CD...
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Article
Effect of Three-minute Cold Exposure in Cryosauna at –70°C on the Human Cellular Immune System
Cell components of the adaptive and innate immunity were investigated in essentially healthy volunteers aged 27 to 34 years. Peripheral blood was analyzed for absolute and relative counts of lymphocyte phenoty...
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Article
Toll-Like Receptors in Peripheral Blood Cells of Cosmonauts after Long-term Missions on Board the International Space Station
Studies of Toll-like receptors (TLR) in 20 cosmonauts, members of long-term (124- to 199-day) missions on board the International Space Station showed changes in the relative and absolute counts of peripheral ...
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Article
The State of the System of Signaling Pattern Recognition Receptors of Monocytes and Granulocytes in the Cosmonauts’ Peripheral Blood before and after Long-Term Flights on Board the International Space Station
The system of signaling pattern recognition receptors was studied in eight cosmonauts at the ages from 35 to 56 years before and after long-term space flights (SFs) on board the International Space Station (IS...
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Article
Bone Mineral Density and Molecular Genetic Markers of Bone Remodeling in Blood of Cosmonauts after Long-term Missions on Board the International Space Station
The results of the investigation of the bone system of 24 Russian cosmonauts after long-term (124–199 days) missions on board the International space station (ISS) are presented. Functional adaptation of the b...
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Article
Adaptive immunity as an indicator of optimum physical loads during 520-day isolation
High stress level in the mechanisms responsible for adaptation to physical work affects the human immune system. Therefore, the effectiveness of countermeasures of reduced physical activity was studied using s...
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Article
Osteoclast-activating system in cosmonauts after long-term international space station missions
The results of studying the system of the osteoprotegerin/receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) in 22 Russian cosmonauts after long-term (124–199 days) International Space Station mis...
