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Open AccessCorrection: Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
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Open AccessGlycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to ther...
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Article
Open AccessThe foundations of the working alliance in assertive community treatment teams
In this study, we aimed to identify and define the fundamental components of the working alliance in multidisciplinary (Flexible) Assertive Community Treatment teams with shared caseloads, in order to support ...
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Article
Open AccessRobust metabolic transcriptional components in 34,494 patient-derived cancer-related samples and cell lines
Patient-derived bulk expression profiles of cancers can provide insight into the transcriptional changes that underlie reprogrammed metabolism in cancer. These profiles represent the average expression pattern...
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Article
Open AccessMentalization and Psychosis: A Rationale for the Use of Mentalization Theory to Understand and Treat Non-affective Psychotic Disorder
Social functioning can be severely impaired in non-affective psychotic disorder (NAPD). Current models of psychosis pathogenesis do not tend to focus on social dysfunction and pharmacological treatment fails t...
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Open AccessGenome-wide expression and response to exposure-based psychological therapy for anxiety disorders
Exposure-based psychological treatments for anxiety have high efficacy. However, a substantial proportion of patients do not respond to therapy. Research examining the potential biological underpinnings of the...
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Article
Open AccessMetacognitive Reflection and Insight Therapy (MERIT) with a Patient with Persistent Negative Symptoms
Metacognition comprises a spectrum of mental activities involving thinking about thinking. Metacognitive impairments may sustain and trigger negative symptoms in people with schizophrenia. Without complex idea...
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Article
Open AccessPeripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid
The blood–brain barrier separates circulating blood from the central nervous system (CNS). The scope of this barrier is not fully understood which limits our ability to relate biological measurements from peri...
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Article
Open AccessElevated mean neutrophil volume represents altered neutrophil composition and reflects damage after myocardial infarction
Myocardial infarction (MI) induces an inflammatory response in which neutrophils fulfill a prominent role. Mean neutrophil volume (MNV) represents the average size of the circulating neutrophil population. Our...
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Het Reumafonds en de reumapatiëntenverenigingen
Het Reumafonds is er voor bijna twee miljoen Nederlanders met een vorm van reuma. Het kan gaan om reumatoïde artritis, artrose of een van de overige honderd chronische aandoeningen aan gewrichten, spieren en p...
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Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid
Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype–phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) cons...
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Common variant at 16p11.2 conferring risk of psychosis
Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as m...
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Article
Open AccessNutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL
Tumour cell-selective activation of apoptosis by recombinant human TNF-related apoptosis-inducing ligand (rhTRAIL) is enhanced through co-activation of p53 by chemotherapeutic drugs. The novel anticancer agent...
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Article
Speed limit of the insulator–metal transition in magnetite
The insulator-to-metal transition occurring in magnetite is known as the Verwey transition, and its precise mechanism has recently come under renewed attention. Using pump–probe X-ray diffraction and optical r...
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Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapy is currently evaluated in clinical studies as a tumor cell selective pro-apoptotic approach. However, besides activating canonical ...
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Nanoscale spin reversal by non-local angular momentum transfer following ultrafast laser excitation in ferrimagnetic GdFeCo
The dynamics of thin magnetic films revealed by ultrafast laser techniques cannot be explained by standard equilibrium descriptions. Diffraction experiments using an X-ray laser now allow the spin dynamics of ...
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Article
Open AccessMonitoring cardiac fibrosis: a technical challenge
The heart contains a collagen network that contributes to the contractility of the heart and provides cardiac strength. In cardiac diseases, an increase in collagen deposition is often observed. This fibrosis ...
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Article
Bilayer manganites reveal polarons in the midst of a metallic breakdown
The origin of colossal magnetoresistance (CMR) in manganese oxides is among the most challenging problems in condensed-matter physics today. The true nature of the low-temperature electronic phase of these mat...
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A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer
Comparing normal colorectal mucosa and adenomas focusing on deregulated pathways obtains insight into the biological processes of early colorectal carcinogenesis. Publicly available microarray expression data ...
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Open AccessDrug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis
Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance.
