Page
%P
-
Article
Open AccessGenome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders
Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. He...
-
Article
Open AccessComprehensive analyses of RNA-seq and genome-wide data point to enrichment of neuronal cell type subsets in neuropsychiatric disorders
Neurological and psychiatric disorders, including substance use disorders, share a range of symptoms, which could be the result of shared genetic background. Many genetic loci have been identified for these di...
-
Chapter
Intoxicaties met hallucinogenen
In het hoofdstuk Intoxicaties met hallucinogenen worden de epidemiologie, aandachtspunten bij anamnese en lichamelijk onderzoek, differentiaaldiagnose en behandelopties besproken. Hallucinogenen veroorzaken va...
-
Book
-
Article
Open AccessIsolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report
Clozapine is an atypical antipsychotic proven to be superior in the treatment of treatment-resistant schizophrenia. Myocarditis is a rare, but well-known complication of treatment with clozapine. Only few case...
-
Article
Open AccessTapering with Pharmaceutical GHB or Benzodiazepines for Detoxification in GHB-Dependent Patients: A Matched-Subject Observational Study of Treatment-as-Usual in Belgium and The Netherlands
The gamma-hydroxybutyric acid (GHB) withdrawal syndrome often has a fulminant course, with a rapid onset and swift progression of severe complications. In clinical practice, two pharmacological regimens are co...
-
Article
Open AccessOutcome reporting bias in randomized-controlled trials investigating antipsychotic drugs
Recent literature hints that outcomes of clinical trials in medicine are selectively reported. If applicable to psychotic disorders, such bias would jeopardize the reliability of randomized clinical trials (RC...
-
Article
Open AccessPeripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid
The blood–brain barrier separates circulating blood from the central nervous system (CNS). The scope of this barrier is not fully understood which limits our ability to relate biological measurements from peri...
-
Article
Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma
The N-methyl-d-aspartate receptor (NMDAR) coagonists glycine, d-serine and l-proline play crucial roles in NMDAR-dependent neurotransmission and are associated with a range of neuropsychiatric disorders. We condu...
-
Article
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid
Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype–phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) cons...
-
Article
Open AccessSeasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR
Studying monoaminergic seasonality is likely to improve our understanding of neurobiological mechanisms underlying season-associated physiological and pathophysiological behavior. Studies of monoaminergic seas...
