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Article
Open AccessPrognostic value of HPV-PCR, p16 and p53 immunohistochemical status on local recurrence rate and survival in patients with vulvar squamous cell carcinoma
The primary aim of this study was to assess the association between human papilloma virus (HPV) and p53 expression and local recurrence (LR), disease specific survival (DSS), and overall survival (OS) in patie...
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Article
Open AccessDiscovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3
Assessment of DNA promoter methylation markers in cervical scra**s for the detection of cervical intraepithelial neoplasia (CIN) and cervical cancer is feasible, but finding methylation markers with both hig...
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Article
Open AccessDNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive women
Primary high-risk human papillomavirus (hrHPV) testing in cervical cancer screening shows relatively low specificity, which makes triage testing necessary. In this study, DNA methylation analysis was compared ...
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Article
Open AccessNutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL
Tumour cell-selective activation of apoptosis by recombinant human TNF-related apoptosis-inducing ligand (rhTRAIL) is enhanced through co-activation of p53 by chemotherapeutic drugs. The novel anticancer agent...
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Article
Open AccessRisk factors for short- and long-term complications after groin surgery in vulvar cancer
The cornerstone of treatment in early-stage squamous cell carcinoma (SCC) of the vulva is surgery, predominantly consisting of wide local excision with elective uni- or bi-lateral inguinofemoral lymphadenectom...
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Article
A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer
Comparing normal colorectal mucosa and adenomas focusing on deregulated pathways obtains insight into the biological processes of early colorectal carcinogenesis. Publicly available microarray expression data ...
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Article
Open AccessDrug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis
Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance.
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Article
Open AccessIdentification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer
Tumour-infiltrating lymphocytes (TILs) are predictors of disease-specific survival (DSS) in ovarian cancer. It is largely unknown what factors contribute to lymphocyte recruitment. Our aim was to evaluate gene...
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Article
Open AccessModest effect of p53, EGFR and HER-2/neu on prognosis in epithelial ovarian cancer: a meta-analysis
P53, EGFR and HER-2/neu are the most frequently studied molecular biological parameters in epithelial ovarian cancer, but their prognostic impact is still unequivocal. We performed a meta-analysis to more prec...
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Article
Open AccessThe ErbB signalling pathway: protein expression and prognostic value in epithelial ovarian cancer
Ovarian cancer is the most frequent cause of death from gynaecological cancer in the Western world. Current prognostic factors do not allow reliable prediction of response to chemotherapy and survival for indi...
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Article
Open AccessReply: The classification of p53 immunohistochemical staining results and patient outcome in ovarian cancer
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Open AccessFactors influencing p53 expression in ovarian cancer as a biomarker of clinical outcome in multicentre studies
The prognostic impact of p53 immunostaining in a large series of tumours from epithelial ovarian cancer patients in a two-centre study was analysed. The study population (n=476) comprised of a retrospective serie...
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Article
Open AccessA phase I and pharmacokinetic study of intraperitoneal topotecan
Purpose: To evaluate the feasibility and pharmacology of intraperitoneal (IP) topotecan. Patients and methods: Fifteen patients with recurrent ovarian cancer in a phase I trial were treated with escalating IP top...
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Article
Open AccessTelomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantation
High-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT) may accelerate telomere length loss in haematopoietic stem cells. As data including pre-and post-treatment samples are lacking, we ...
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Article
Open AccessOvarian cysts in women receiving tamoxifen for breast cancer
Tamoxifen is a nonsteroidal anti-oestrogen with gynaecological side-effects. Only recently, ovarian cyst formation during tamoxifen treatment has been reported. The present study aimed to evaluate patient-rela...
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Article
Open AccessDNA topoisomerase IIα and -β expression in human ovarian cancer
To study DNA topoisomerase IIα (Topo-IIα) and -β expression and regulation in human ovarian cancer, 15 ovarian tumour samples were investigated. To compare different levels of expression, the samples were scre...
