112 Result(s)

Article

Population structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert

Analyzing the genetic diversity and selection characteristics of sheep (Ovis aries) holds significant value in understanding their environmental adaptability, enhancing breeding efficiency, and achieving effec...

Zhi-peng Han, Rui-zhi Yang, Wen Zhou, Lu-lu Zhang, Jie-ru Wang… in BMC Genomics (2024)

Article

Integration of large and diverse angiosperm DNA fragments into Asian Gnetum mitogenomes

Horizontal gene transfer (HGT) events have rarely been reported in gymnosperms. Gnetum is a gymnosperm genus comprising 25‒35 species sympatric with angiosperms in West African, South American, and Southeast Asia...

Chung-Shien Wu, Rui-Jiang Wang, Shu-Miaw Chaw in BMC Biology (2024)

Article

Establishment of an in vitro model of monocyte-like THP-1 cells for trained immunity induced by bacillus Calmette-Guérin

Mycobacteria bloodstream infections are common in immunocompromised people and usually have disastrous consequences. As the primary phagocytes in the bloodstream, monocytes and neutrophils play critical roles ...

**-Chuan Xu, Kang Wu, Rui-qing Ma, Jian-hui Li, Jie Tao, Zhidong Hu… in BMC Microbiology (2024)

Article

Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...

**ao-yun Niu, **-xiu **e, Hou-zhen Tuo, Cui-** Lv, Ya-ru Huang… in Cell Death Discovery (2024)

Article

Karyotype and LTR-RTs analysis provide insights into oak genomic evolution

Whole-genome duplication and long terminal repeat retrotransposons (LTR-RTs) amplification in organisms are essential factors that affect speciation, local adaptation, and diversification of organisms. Underst...

Rui-Bin Cao, Ran Chen, Ke-**n Liao, He Li, Gang-Biao Xu, **ao-Long Jiang in BMC Genomics (2024)

Article

Activation of GPR81 by lactate drives tumour-induced cachexia

Cachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-related death, but the underlying mechanism driving cachexia remains elusive. Here we show that circulating lactate levels positiv...

**dan Liu, Shi** Li, Qionghua Cui, Bu**g Guo, Wanqiu Ding, Jie Liu… in Nature Metabolism (2024)

Article

Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells

Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeabil...

Yu-Shan Lin, Zhiwei Sun, Li-Sha Shen, Rui-Hong Gong, Jia-Wen Chen… in Cell Death Discovery (2024)

Article

IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1

Matrix metalloproteinase-1 (MMP1) has an aberrant expression relevant to various behaviors of cancers. As dominant components of the tumor stroma, fibroblasts constitute an important source of Matrix metallopr...

Yu Chen, Li Huang, Rui-Huan Gan, Shuo Yuan, Ting Lan, Dali Zheng… in Cell Death Discovery (2024)

Article

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated, voltage-dependent channels of the ionotropic glutamate receptor family. The present study explored whether NMDAR activation induced ferroptosis in vasc...

Wei-Min Han, Yi-**ang Hong, Guo-Sheng **ao, Rui-Ying Wang, Gang Li in Cell Death Discovery (2024)

Article

Targeting the E2F1/Rb/HDAC1 axis with the small molecule HR488B effectively inhibits colorectal cancer growth

Colorectal cancer (CRC), the third most common cancer worldwide, remains highly lethal as the disease only becomes symptomatic at an advanced stage. Growing evidence suggests that histone deacetylases (HDACs),...

Namin Duan, **aohui Hu, Huiran Qiu, Rui Zhou, Yuru Li, Wenxia Lu… in Cell Death & Disease (2023)

Article

PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity

Combination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy comparing to monotherapy. The underlying mechanisms responsible for the synergistic effects of the combination therapy...

Rui Liu, Lin-Wen Zeng, Hui-Fang Li, Jun-Ge Shi, Bo Zhong, Hong-Bing Shu… in Cell Research (2023)

Article

RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment

Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly expressed in arterial VSMCs and pericytes, which is involved in VSMC phenotypic hete...

Peng Kong, Xu Wang, Ya-Kun Gao, Dan-Dan Zhang, **ao-Fu Huang, Yu Song… in Biology Direct (2023)

Article

YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions

Maladaptive repair of acute kidney injury (AKI) is associated with a high risk of develo** chronic kidney disease deemed irremediable even in present days. When AKI arises from ischemia-reperfusion injury, h...

Heng-Ai Chang, Rui-Zhi Ou Yang, **g-Ming Su, Thi My Hang Nguyen… in Cell Death Discovery (2023)

Article

MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages

Activation of the NLRP3 inflammasome is a two-step process: the priming and the activating. The priming step involves the induction of NLRP3 and pro-IL-1β, while the activating step leads to the full inflammas...

Huachun Cui, Sami Banerjee, Na **e, Tapan Dey, Rui-Ming Liu… in Communications Biology (2023)

Article

Author Correction: Genomic insights into biased allele loss and increased gene numbers after genome duplication in autotetraploid Cyclocarya paliurus

Rui-Min Yu, Ning Zhang, Bo-Wen Zhang, Yu Liang, **ao-Xu Pang, Lei Cao… in BMC Biology (2023)

Article

Structural and functional analyses of Burkholderia pseudomallei BPSL1038 reveal a Cas-2/VapD nuclease sub-family

Burkholderia pseudomallei is a highly versatile pathogen with ~25% of its genome annotated to encode hypothetical proteins. One such hypothetical protein, BPSL1038, is conserved across seven bacterial genera and ...

Sofiyah Shaibullah, Nurshahirah Shuhaimi, De-Sheng Ker… in Communications Biology (2023)

Article

Genomic insights into biased allele loss and increased gene numbers after genome duplication in autotetraploid Cyclocarya paliurus

Autopolyploidy is a valuable model for studying whole-genome duplication (WGD) without hybridization, yet little is known about the genomic structural and functional changes that occur in autopolyploids after ...

Rui-Min Yu, Ning Zhang, Bo-Wen Zhang, Yu Liang, **ao-Xu Pang, Lei Cao… in BMC Biology (2023)

Article

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions

Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...

He-Wei Jiang, Hong Chen, Yun-**ao Zheng, Xue-Ning Wang… in Science China Life Sciences (2023)

Article

Stem cell-derived intestinal organoids: a novel modality for IBD

The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissu...

Cheng-mei Tian, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu… in Cell Death Discovery (2023)

Article

TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m⁷G methylation of ATF5 mRNA

The mitochondrial transmembrane (TMEM) protein family has several essential physiological functions. However, its roles in cardiomyocyte proliferation and cardiac regeneration remain unclear. Here, we detected...

**n-Zhe Chen, **n-Min Li, Shi-Jun Xu, Shen Hu, Tao Wang… in Cell Death & Differentiation (2023)