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  1. No Access

    Article

    Structural basis of HIV-1 resistance to AZT by excision

    AZT is a nucleoside analog drug that inhibits HIV-1 reverse transcriptase (RT). The viral enzyme can acquire AZT resistance by mutations that enhance the rate of ATP-mediated excision of the incorporated AZT. ...

    **ongying Tu, Kalyan Das, Qianwei Han… in Nature Structural & Molecular Biology (2010)

  2. No Access

    Article

    Aminoglycoside antibiotics induce bacterial biofilm formation

    Bacteria commonly form adherent cell aggregates or biofilms in which they become resistant to killing by antibiotics. Now in a surprising development, commonly used aminoglycoside antibiotics at subinhibitory ...

    Lucas R. Hoffman, David A. D'Argenio, Michael J. MacCoss, Zhaoying Zhang… in Nature (2005)

  3. No Access

    Article

    Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

    Tenofovir, also known as PMPA, R-9-(2-(phosphonomethoxypropyl)adenine, is a nucleotide reverse transcriptase (RT) inhibitor. We have determined the crystal structures of two related complexes of HIV-1 RT with tem...

    Steve Tuske, Stefan G Sarafianos… in Nature Structural & Molecular Biology (2004)

  4. No Access

    Article

    Bombyx mori single repeat telomeric DMA sequence forms a G-quadruplex capped by base triads

    A combined NMR–molecular dynamics approach has been applied to determine the solution structure of a truncated analogue of the Bombyx mori telomeric d(TTAGG) single repeat sequence in Na+ cation-containing aqueou...

    Abdelali Kettani, Serge Bouaziz, Weimin Wang, Roger A. Jones… in Nature Structural Biology (1997)

  5. No Access

    Article

    Specific labeling approaches to guanine and adenine imino and amino proton assignments in the AMP–RNA aptamer complex

    The secondary structure of a recently identified ATP-binding RNA aptamer consists of apurine-rich 11-residue internal loop positioned opposite a single guanine bulge flanked oneither side by helical stem segme...

    Feng Jiang, Dinshaw J. Patel, **aohu Zhang, Hong Zhao… in Journal of Biomolecular NMR (1997)

  6. No Access

    Article

    Structural basis of RNA folding and recognition in an AMP–RNA aptamer complex

    THE catalytic properties of RNA1,2 and its well known role in gene expression and regulation are the consequence of its unique solution structures. Identification of the structural determinants of ligand recognit...

    Feng Jiang, R. Ajay Kumar, Roger A. Jones, Dinshaw J. Patel in Nature (1996)

  7. No Access

    Protocol

    Synthesis of [15N]-Labeled DNA Fragments

    DNA fragments labeled with 15N have the potential to provide novel insight into base pairing, hydration, drug/nucleic acid, and protein/ nucleic acid interactions. Synthetic routes to a variety of [15N]-labeled p...

    Roger A Jones in Protocols for Oligonucleotide Conjugates (1994)

  8. No Access

    Article

    Evaluation of a chemically defined model for the attachment of 3,4-dichloroaniline to humus

    In -Soon You, Roger A. Jones, Richard Bartha in Bulletin of Environmental Contamination an… (1982)