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  1. Article

    Open Access

    Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics

    Caspase-2 (Casp2) is a promising therapeutic target in several human diseases, including nonalcoholic steatohepatitis (NASH) and Alzheimer’s disease (AD). However, the design of an active-site-directed inhibit...

    Elodie Bosc, Julie Anastasie, Feryel Soualmia, Pascale Coric… in Cell Death & Disease (2022)

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  2. No Access

    Article

    1H, 13C and 15N backbone resonance assignment of HIV-1 Gag (276–432) encompassing the C-terminal domain of the capsid protein, the spacer peptide 1 and the nucleocapsid protein

    During the maturation of the HIV-1 particle, the Gag polyprotein is cleaved by the viral protease into several proteins: matrix (MA), capsid (CA), spacer peptide 1 (SP1), nucleocapsid (NC), spacer peptide 2 (S...

    **aowei Chen, Pascale Coric, Serge Bouaziz in Biomolecular NMR Assignments (2021)

  3. Article

    Open Access

    The three lives of Pierre Boulanger

    Nathalie Chazal, Hugues de Rocquigny, Philippe Roussel, Serge Bouaziz… in Retrovirology (2020)

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  4. No Access

    Article

    Backbone resonance assignment of the human uracil DNA glycosylase-2

    The HIV-1 viral protein R (Vpr) is incorporated into virus particle during budding suggesting that its presence in the mature virion is required in the early steps of the virus life cycle in newly infected cel...

    Hesna Kara, Luc Ponchon, Serge Bouaziz in Biomolecular NMR Assignments (2018)

  5. Article

    Open Access

    The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain

    DSB, the 3-O-(3',3'dimethylsuccinyl) derivative of betulinic acid, blocks the last step of protease-mediated processing of HIV-1 Gag precursor (Pr55Gag), which leads to immature, noninfectious virions. When admin...

    Sandrina DaFonseca, Pascale Coric, Bernard Gay, Saw See Hong… in Virology Journal (2008)

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  6. Article

    Open Access

    Direct Vpr-Vpr Interaction in Cells monitored by two Photon Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging

    The human immunodeficiency virus type 1 (HIV-1) encodes several regulatory proteins, notably Vpr which influences the survival of the infected cells by causing a G2/M arrest and apoptosis. Such an important ro...

    Joëlle V Fritz, Pascal Didier, Jean-Pierre Clamme, Emmanuel Schaub… in Retrovirology (2008)

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  7. Article

    Open Access

    Localization of HIV-1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages

    HIV-1 Vpr is a dynamic protein that primarily localizes in the nucleus, but a significant fraction is concentrated at the nuclear envelope (NE), supporting an interaction between Vpr and components of the nucl...

    Guillaume Jacquot, Erwann Le Rouzic, Annie David, Julie Mazzolini… in Retrovirology (2007)

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  8. No Access

    Article

    Bombyx mori single repeat telomeric DMA sequence forms a G-quadruplex capped by base triads

    A combined NMR–molecular dynamics approach has been applied to determine the solution structure of a truncated analogue of the Bombyx mori telomeric d(TTAGG) single repeat sequence in Na+ cation-containing aqueou...

    Abdelali Kettani, Serge Bouaziz, Weimin Wang, Roger A. Jones… in Nature Structural Biology (1997)