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    Structural basis of HIV-1 resistance to AZT by excision

    AZT is a nucleoside analog drug that inhibits HIV-1 reverse transcriptase (RT). The viral enzyme can acquire AZT resistance by mutations that enhance the rate of ATP-mediated excision of the incorporated AZT. ...

    **ongying Tu, Kalyan Das, Qianwei Han… in Nature Structural & Molecular Biology (2010)