-
Article
Open AccessCharacteristics and outcome of acute myeloid leukemia with uncommon retinoic acid receptor-alpha (RARA) fusion variants
-
Article
Risk Of Thrombosis In Elderly Immune Primary Trombocytopenic Patients Treated with Thrombopoietin Receptors Agonists
-
Article
High Energy Spine Injury Alternate Multiple Fractures Observational Retrospective Study
Multiple alternate fractures are those that present injuries at several levels of the spine separated by at least one healthy vertebral body. A posttraumatic prevalence of up to 23% is reported.3–5 There are no r...
-
Article
Ibrutinib related bleeding complications in elderly patients with B cell malignancies
-
Article
Increased risk of heparin induced thrombocytopenia and thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation
-
Article
Clinical characteristics and treatment outcome of an 86-year-old patient with acute myeloid leukaemia with acute promyelocytic-like morphology and uncommon RARA fusion variant
-
Article
Parameterization of Invariant Manifolds for Periodic Orbits (II): A Posteriori Analysis and Computer Assisted Error Bounds
In this paper we develop mathematically rigorous computer assisted techniques for studying high order Fourier–Taylor parameterizations of local stable/unstable manifolds for hyperbolic periodic orbits of analy...
-
Article
Splenic marginal zone lymphomas in acquired C1-inhibitor deficiency: clinical and molecular characterization
Angioedema due to acquired deficiency of the inhibitor of the first component of complement (C1-INH) is a rare disease known as acquired angioedema (AAE). About 70% of patients with AEE display autoantibodies ...
-
Article
Management of anemia in low-risk myelodysplastic syndromes treated with erythropoiesis-stimulating agents newer and older agents
The myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders. The International Prognostic Score System (IPSS) groups MDS in lower-risk (IPSS low and intermediate-1) and higher-risk diseas...
-
Article
Rigorous Numerics for ill-posed PDEs: Periodic Orbits in the Boussinesq Equation
In this paper, we develop computer-assisted techniques for the analysis of periodic orbits of ill-posed partial differential equations. As a case study, our proposed method is applied to the Boussinesq equatio...
-
Article
The impact of anaemia, transfusion dependency, comorbidities and polypharmacy in elderly patients with low-risk myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are heterogeneous clonal disorders ranging from indolent conditions with a near-normal life expectancy to forms approaching acute myeloid leukaemia. Comorbid conditions have rar...
-
Article
High prevalence of heparin induced thrombocytopenia with thrombosis among patients with essential thrombocytemia carrying V617F mutation
Arterial and venous complications are major causes of morbidity and mortality in myeloproliferative neoplasms (MPNs). MPNs patients, frequently receive heparin. Heparin-induced thrombocytopenia (HIT) is a rare...
-
Article
First-line treatment with bendamustine and rituximab, in patients with intermediate-/high-risk splenic marginal zone lymphomas
Splenic marginal zone lymphomas (SMZLs) are rare indolent B cell neoplasms that affect the spleen, bone marrow, and blood. Although they have an indolent course in the majority of patients, who have a median s...
-
Article
Open AccessRigorous Computation of Non-uniform Patterns for the 2-Dimensional Gray-Scott Reaction-Diffusion Equation
In this paper a method to rigorously compute several non trivial solutions of the Gray-Scott reaction-diffusion system defined on a 2-dimensional bounded domain is presented. It is proved existence, within rig...
-
Article
Biosimilar epoetin alfa increases haemoglobin levels and brings cognitive and socio-relational benefits to elderly transfusion-dependent multiple myeloma patients: results from a pilot study
Anaemia is a complication reported in up to 70% of the multiple myeloma patients (MM), with remarkable clinical, cognitive and socio-relational consequences. Anaemia relates to the course of MM, normalizing in...
-
Article
Efficient design of direct low-energy transfers in multi-moon systems
In this contribution, an efficient technique to design direct (i.e., without intermediate flybys) low-energy trajectories in multi-moon systems is presented. The method relies on analytical two-body approximat...
-
Article
Open AccessTopologically Distinct Collision-Free Periodic Solutions for the \({N}\) -Center Problem
This work concerns the planar \({N}\) N ...
-
Chapter and Conference Paper
Two-Body Approximations in the Design of Low-Energy Transfers Between Galilean Moons
Over the past two decades, the robotic exploration of the Solar System has reached the moons of the giant planets. In the case of Jupiter, a strong scientific interest towards its icy moons has motivated impor...
-
Article
Analytic enclosure of the fundamental matrix solution
This work describes a method to rigorously compute the real Floquet normal form decomposition of the fundamental matrix solution of a system of linear ODEs having periodic coefficients. The Floquet normal form...
-
Article
Biosimilar epoetin in elderly patients with low-risk myelodysplastic syndromes improves anemia, quality of life, and brain function
The myelodysplastic syndromes (MDS) are a group of clonal hematopoietic disorders characterized by bone marrow failure and a risk of progression to acute myeloid leukemia (AML). Anemia affects the course of di...
