19 Result(s)
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Article
Risk Of Thrombosis In Elderly Immune Primary Trombocytopenic Patients Treated with Thrombopoietin Receptors Agonists
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Article
Ibrutinib related bleeding complications in elderly patients with B cell malignancies
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Article
Increased risk of heparin induced thrombocytopenia and thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation
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Article
Management of anemia in low-risk myelodysplastic syndromes treated with erythropoiesis-stimulating agents newer and older agents
The myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders. The International Prognostic Score System (IPSS) groups MDS in lower-risk (IPSS low and intermediate-1) and higher-risk diseas...
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Article
The impact of anaemia, transfusion dependency, comorbidities and polypharmacy in elderly patients with low-risk myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are heterogeneous clonal disorders ranging from indolent conditions with a near-normal life expectancy to forms approaching acute myeloid leukaemia. Comorbid conditions have rar...
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Article
High prevalence of heparin induced thrombocytopenia with thrombosis among patients with essential thrombocytemia carrying V617F mutation
Arterial and venous complications are major causes of morbidity and mortality in myeloproliferative neoplasms (MPNs). MPNs patients, frequently receive heparin. Heparin-induced thrombocytopenia (HIT) is a rare...
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Article
First-line treatment with bendamustine and rituximab, in patients with intermediate-/high-risk splenic marginal zone lymphomas
Splenic marginal zone lymphomas (SMZLs) are rare indolent B cell neoplasms that affect the spleen, bone marrow, and blood. Although they have an indolent course in the majority of patients, who have a median s...
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Article
Biosimilar epoetin alfa increases haemoglobin levels and brings cognitive and socio-relational benefits to elderly transfusion-dependent multiple myeloma patients: results from a pilot study
Anaemia is a complication reported in up to 70% of the multiple myeloma patients (MM), with remarkable clinical, cognitive and socio-relational consequences. Anaemia relates to the course of MM, normalizing in...
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Article
Biosimilar epoetin in elderly patients with low-risk myelodysplastic syndromes improves anemia, quality of life, and brain function
The myelodysplastic syndromes (MDS) are a group of clonal hematopoietic disorders characterized by bone marrow failure and a risk of progression to acute myeloid leukemia (AML). Anemia affects the course of di...
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Article
Neuroprotective effects of human mesenchymal stem cells on neural cultures exposed to 6-hydroxydopamine: implications for reparative therapy in Parkinson’s disease
Stem cell (SC) transplantation represents a promising tool to treat neurodegenerative disorders, such as Parkinson’s disease (PD), but positive therapeutic outcomes require elucidation of the biological mechan...
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Article
Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis
The Inhibitor of Apoptosis Proteins (IAPs) are important regulators of programmed cell death. XIAP is the most potent among them and is over-expressed in several hematological malignancies. Its activity is end...
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Article
Metalloproteinase alterations in the bone marrow of ALS patients
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, nowadays considered as suitable candidate for autologous stem therapy with bone marrow (BM). A careful characterization of BM stem cell...
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Article
Open AccessAn integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma
The role of microRNAs (miRNAs) in multiple myeloma (MM) has yet to be fully elucidated. To identify miRNAs that are potentially deregulated in MM, we investigated those map** within transcription units, base...
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Article
Survivin expression in “low-risk” and “high-risk” myelodysplastic syndromes
Apoptosis has a crucial role in myelodysplastic syndromes (MDS), being responsible of the ineffective hematopoiesis characteristic of the disease. Apoptosis rate is elevated in “early phase” MDS, whereas it di...
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Article
Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential
The main goal of the study was to identify a novel source of human multipotent cells, overcoming ethical issues involved in embryonic stem cell research and the limited availability of most adult stem cells. A...
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Chapter
Clinical Sensitivity to Anthracyclines in PH/BCR+ Acute Lymphoblastic Leukemia
Translocation t(9;22) or Philadelphia chromosome (Ph)/BCR-ABL rearrangement positive acute lymphoblastic leukemia (Ph/BCR+ ALL) is associated with a very short survival of about one year in most patients.We an...
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Chapter and Conference Paper
Heterogeneous Expression of Myelo-Monocytic Markers on Selected Non-Lymphoid Cells
We have analyzed the early steps of the myelo-monocytic commitment and the dissection of the granulocytic from the monocytic differentiation pathway by using acute leukemias as a model. We have selected fresh ...
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Chapter
The Ultrastructure of Monocytic Leukemia
The concept of a leukemia characterized almost exclusively by malignanc monocyric cells was first suggested in 1913 by Schilling [1] and subsequently included in the FAB classification [2] as M5a (poorly differen...
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Chapter and Conference Paper
Ultrastructural Alterations Induced in Hepatic Cell Nucleoli by Adriamycin
During the last ten years cell lesions due to chemical compounds, and particularly to those antibiotics with antitumoral activity, have promoted numerous ultrastructural studies. As some of these agents interf...
