-
Article
Open AccessExtant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial
Ninu (greater bilby, Macrotis lagotis) are desert-dwelling, culturally and ecologically important marsupials. In collaboration with Indigenous rangers and conservation managers, we generated the Ninu chromosome-l...
-
Article
Open AccessSensory and motor electrophysiological map** of the cerebellum in humans
Cerebellar damage during posterior fossa surgery in children can lead to ataxia and risk of cerebellar mutism syndrome. Compartmentalisation of sensorimotor and cognitive functions within the cerebellum have b...
-
Article
Open AccessChromosome-length genome assembly and structural variations of the primal Basenji dog (Canis lupus familiaris) genome
Basenjis are considered an ancient dog breed of central African origins that still live and hunt with tribesmen in the African Congo. Nicknamed the barkless dog, Basenjis possess unique phylogeny, geographical...
-
Article
Open AccessThe Extracellular Domain of Two-component System Sensor Kinase VanS from Streptomyces coelicolor Binds Vancomycin at a Newly Identified Binding Site
The glycopeptide antibiotic vancomycin has been widely used to treat infections of Gram-positive bacteria including Clostridium difficile and methicillin-resistant Staphylococcus aureus. However, since its introd...
-
Protocol
Computational Prediction of Disordered Protein Motifs Using SLiMSuite
Short linear motifs (SLiMs) are important mediators of interactions between intrinsically disordered regions of proteins and their interaction partners. Here, we detail instructions for the computational predi...
-
Chapter
Tumors of Germ Cell Origin
Central nervous system germ cell tumors (GCTs) are a relatively rare and heterogeneous group of tumors. In general, they are more commonly seen in the Asian population, have a male preponderance, and commonly ...
-
Article
Open AccessHigh risk human papilloma viruses (HPVs) are present in benign prostate tissues before development of HPV associated prostate cancer
Although high risk HPVs are associated with an increased risk of prostate cancer it is not known if they have a causal role. The purpose of this study is to investigate the potential role of human papilloma vi...
-
Article
Open AccessTranscriptome analysis of human brain tissue identifies reduced expression of complement complex C1Q Genes in Rett syndrome
MECP2, the gene mutated in the majority of Rett syndrome cases, is a transcriptional regulator that can activate or repress transcription. Although the transcription regulatory function of MECP2 has been known...
-
Protocol
Computational Prediction of Short Linear Motifs from Protein Sequences
Short Linear Motifs (SLiMs) are functional protein microdomains that typically mediate interactions between a short linear region in one protein and a globular domain in another. SLiMs usually occur in structu...
-
Article
Shotgun Proteomic Analysis of Emiliania huxleyi, a Marine Phytoplankton Species of Major Biogeochemical Importance
Emiliania huxleyi is a unicellular marine phytoplankton species known to play a significant role in global biogeochemistry. Through the dual roles of photosynthesis and production of calcium carbonate (calcificat...
-
Article
Open AccessEstimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated proteins
Large datasets of protein interactions provide a rich resource for the discovery of Short Linear Motifs (SLiMs) that recur in unrelated proteins. However, existing methods for estimating the probability of mot...
-
Chapter and Conference Paper
SLiMSearch: A Webserver for Finding Novel Occurrences of Short Linear Motifs in Proteins, Incorporating Sequence Context
Short, linear motifs (SLiMs) play a critical role in many biological processes. The SLiMSearch (Short, Linear Motif Search) webserver is a flexible tool that enables researchers to identify novel occurrences o...
-
Article
Bioinformatic discovery of novel bioactive peptides
-
Article
Open AccessTandem repeat copy-number variation in protein-coding regions of human genes
Tandem repeat variation in protein-coding regions will alter protein length and may introduce frameshifts. Tandem repeat variants are associated with variation in pathogenicity in bacteria and with human disea...
-
Article
Open AccessGASP: Gapped Ancestral Sequence Prediction for proteins
The prediction of ancestral protein sequences from multiple sequence alignments is useful for many bioinformatics analyses. Predicting ancestral sequences is not a simple procedure and relies on accurate align...
-
Article
A quantitative comparison of plaque types in Alzheimer’s disease and senile dementia of the Lewy body type
In a previous study we reported no difference in the overall β-amyloid protein (βAP) load between Alzheimer’s disease (AD) and senile dementia of the Lewy body type (SDLT). However, it is possible that differ...
