Skip to main content

9 Result(s)

within Marc Devocelle Remove this filter

and

  1. No Access

    Article

    Biosynthesis of 2-aminooctanoic acid and its use to terminally modify a lactoferricin B peptide derivative for improved antimicrobial activity

    Terminal modification of peptides is frequently used to improve their hydrophobicity. While N-terminal modification with fatty acids (lipidation) has been reported previously, C-terminal lipidation is limited ...

    Sarah A. Almahboub, Tanja Narancic… in Applied Microbiology and Biotechnology (2018)

  2. No Access

    Article

    Stabilization of Angiotensin-(1–7) by key substitution with a cyclic non-natural amino acid

    Angiotensin-(1–7) [Ang-(1–7)], a heptapeptide hormone of the renin–angiotensin–aldosterone system, is a promising candidate as a treatment for cancer that reflects its anti-proliferative and anti-angiogenic pr...

    Anita Wester, Marc Devocelle, E. Ann Tallant, Mark C. Chappell… in Amino Acids (2017)

  3. No Access

    Protocol

    Using Disease-Associated Enzymes to Activate Antimicrobial Peptide Prodrugs

    Prodrugs of antimicrobial peptides can be generated by modifying their sequences at their N-termini with a linker and a negatively charged promoiety. These modifications can be selectively reversed by a diseas...

    Éanna B. Forde, Graeme Kelly, Hisham Makki, Zahraa Al-Sharshahi… in Antimicrobial Peptides (2017)

  4. Article

    Open Access

    In vitro evaluation of a prodrug approach for Gly-D-P18, a host defence peptide and novel anticancer agent

    A Hsu, Marc Devocelle, Joseph Ward, Stephen Keely in BMC Proceedings (2015)

    Download PDF (205 KB) View Article

  5. No Access

    Protocol

    Computational Approaches to Develo** Short Cyclic Peptide Modulators of Protein–Protein Interactions

    Cyclic peptides are a promising class of bioactive molecules potentially capable of modulating “difficult” targets, such as protein–protein interactions. Cyclic peptides have long been used as therapeutics der...

    Fergal J. Duffy, Marc Devocelle, Denis C. Shields in Computational Peptidology (2015)

  6. Article

    Open Access

    Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions

    Bioactive cyclic peptides derived from natural sources are well studied, particularly those derived from non-ribosomal synthetases in fungi or bacteria. Ribosomally synthesised bioactive disulphide-bonded loop...

    Fergal J Duffy, Marc Devocelle, David R Croucher, Denis C Shields in BMC Bioinformatics (2014)

    Download PDF (547 KB) View Article

  7. No Access

    Article

    In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery

    Development of RNA interference based therapeutics for neurological and neurodegenerative diseases is hindered by a lack of non-viral vectors with suitable properties for systemic administration. Amphiphilic a...

    Aoife M. O’Mahony, Stephane Desgranges, Julien Ogier… in Pharmaceutical Research (2013)

  8. No Access

    Article

    Bioinformatic discovery of novel bioactive peptides

    Richard J Edwards, Niamh Moran, Marc Devocelle, Aoife Kiernan… in Nature Chemical Biology (2007)

  9. No Access

    Chapter and Conference Paper

    Peptidomimetic Inhibitors of Platelet Adhesion as Potential Novel Antiplatelet Agents

    Vivienne Buckley, Elise Bernard, Edelmiro Moman… in Understanding Biology Using Peptides (2006)