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Open AccessComputational modelling of chromosomally clustering protein domains in bacteria
In bacteria, genes with related functions—such as those involved in the metabolism of the same compound or in infection processes—are often physically close on the genome and form groups called clusters. The e...
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Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper.
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure...
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Article
Open AccessEvolutionary instability of CUG-Leu in the genetic code of budding yeasts
The genetic code used in nuclear genes is almost universal, but here we report that it changed three times in parallel during the evolution of budding yeasts. All three changes were reassignments of the codon ...
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Correction: Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Nat. Genet.; doi:10.1038/ng.3768; corrected online 20 February 2017 In the version of this article initially published online, the name of Chiara Batini was misspelled as Chiara Battini in the list of collabor...
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Article
Functional characterisation of the YIPF protein family in mammalian cells
In this study, we carry out a systematic characterisation of the YIPF family of proteins with respect to their subcellular localisation profile, membrane topology and functional effects on the endomembrane sys...
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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biolo...
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Challenges and Opportunities in Clinical Bioinformatics
Clinically applied bioinformatics faces many specific challenges. Many of these are related to challenges faced by discovery bioinformatics, which is confronted by similar issues of data complexity, data scale...
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Article
Open AccessGenome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression
Epistasis (synergistic interaction) among SNPs governing gene expression is likely to arise within transcriptional networks. However, the power to detect it is limited by the large number of combinations to be...
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Protocol
Computational Approaches to Develo** Short Cyclic Peptide Modulators of Protein–Protein Interactions
Cyclic peptides are a promising class of bioactive molecules potentially capable of modulating “difficult” targets, such as protein–protein interactions. Cyclic peptides have long been used as therapeutics der...
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Open AccessPharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-a...
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Open AccessComputational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions
Bioactive cyclic peptides derived from natural sources are well studied, particularly those derived from non-ribosomal synthetases in fungi or bacteria. Ribosomally synthesised bioactive disulphide-bonded loop...
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Article
SCL-Epred: a generalised de novo eukaryotic protein subcellular localisation predictor
Knowledge of the subcellular location of a protein provides valuable information about its function, possible interaction with other proteins and drug targetability, among other things. The experimental determ...
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Article
Open AccessSLiMScape: a protein short linear motif analysis plugin for Cytoscape
Computational protein short linear motif discovery can use protein interaction information to search for motifs among proteins which share a common interactor. Cytoscape provides a visual interface for protein...
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Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conducti...
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Article
Open AccessProfile-based short linear protein motif discovery
Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3–10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods hav...
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Article
Open AccessA novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication sk...
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Open AccessDistinct configurations of protein complexes and biochemical pathways revealed by epistatic interaction network motifs
Gene and protein interactions are commonly represented as networks, with the genes or proteins comprising the nodes and the relationship between them as edges. Motifs, or small local configurations of edges an...
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Open AccessShift in the isoelectric-point of milk proteins as a consequence of adaptive divergence between the milks of mammalian species
Milk proteins are required to proceed through a variety of conditions of radically varying pH, which are not identical across mammalian digestive systems. We wished to investigate if the shifts in these requireme...
