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  1. Article

    Open Access

    Onionin A inhibits small-cell lung cancer proliferation through suppressing STAT3 activation induced by macrophages-derived IL-6 and cell–cell interaction with tumor-associated macrophage

    Tumor-associated macrophage (TAM)-derived IL-6 is involved in small-cell lung cancer (SCLC) progression and chemoresistance via the activation of signal transducer and activator of transcription 3 (STAT3) in t...

    Remi Mito, Toyohisa Iriki, Yukio Fujiwara, Cheng Pan, Tsuyoshi Ikeda in Human Cell (2023)

  2. Article

    The expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms in lung adenocarcinoma

    Programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) are target molecules for immunotherapy in non-small cell lung cancer. PD-L1 is expressed not only in cancer cells, but also on macrophages, and has been...

    Yusuke Shinchi, Shiho Ishizuka, Yoshihiro Komohara in Cancer Immunology, Immunotherapy (2022)