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  1. No Access

    Article

    IL-32 production from lung adenocarcinoma cells is potentially involved in immunosuppressive microenvironment

    Interleukin 32 (IL-32) is a proinflammatory cytokine secreted from several kinds of cancer cells. In the present study, we investigated the significance of IL-32 in lung adenocarcinoma by immunohistochemistry ...

    Shukang Zhao, Lianbo Li, Yoshihiro Komohara, Eri Matsubara… in Medical Molecular Morphology (2024)

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    Article

    PD-L2 overexpression on tumor-associated macrophages is one of the predictors for better prognosis in lung adenocarcinoma

    Immunotherapies that target programmed cell death protein 1 (PD-1) signals are standard therapies for advanced-stage lung cancer, and the expression of programmed death-ligand 1 (PD-L1) in cancer tissue predic...

    Eri Matsubara, Yusuke Shinchi, Yoshihiro Komohara… in Medical Molecular Morphology (2023)

  3. Article

    The expression of PD-1 ligand 1 on macrophages and its clinical impacts and mechanisms in lung adenocarcinoma

    Programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) are target molecules for immunotherapy in non-small cell lung cancer. PD-L1 is expressed not only in cancer cells, but also on macrophages, and has been...

    Yusuke Shinchi, Shiho Ishizuka, Yoshihiro Komohara… in Cancer Immunology, Immunotherapy (2022)

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