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Article
Cirrhosis in a child with hypothalamic syndrome and central precocious puberty treated with cyproterone acetate
Before the advent of gonadotropin-releasing-hormone analogues, cyproterone acetate (CPA) had been widely prescribed for the treatment of precocious puberty. Although it is usually well tolerated, liver toxici...
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Article
Central precocious puberty: Evaluation by neuroimaging
To evaluate the incidence of abnormal intracranial findings in children with central precocious puberty, 62 children (51 girls, 11 boys) were examined by computerized tomography and/or magnetic resonance imagi...
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Article
HYPERANDROGENISM AS A CAUSE OF EARLY POLYCYSTIC OVARY SYNDROME (PCOS) IN GIRLS WITH CENTRAL PRECOCIOUS PUBERTY (CPP)
Increased adrenal androgens are often observed in girls with CPP. The hyperandrogenism is not affected by the therapy with GnRh analog (GnRHA). We performed an i.v. ACTH stimulation test (0.25mg) in 42 girls w...
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Chapter
Long Term Experience with a Superactive GnRH Analog in the Treatment of Precocious Puberty
Since 1960 we have treated in our Institute 209 children with central (true) precocious puberty (CPP). Out of these only 2 male patients had CNS tumors (optic nerve glioma and glioblastoma), in the others the ...
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Article
135 PUBERTAL DEVELOPMENT AND FINAL HEIGHT IN CIRLS WITH CENTRAL PRECOCIOUS PUBERTY (CPP) AFTER THERAPY WITH THE Gn-RII ANALOC D-TRP-6-LII-RII
Fifteen girls with CPP who have been treated with D-TRP-6-LH-RII (13 daily s.c.; 2 monthly i.m.) for 1 to 5 yrs were followed after therapy for 6 months to 4 yrs. Resumption of pubertal developmont was evident...
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Article
GROWTH HORMONE (GH) IS NORMAL IN GIRLS WITH PRECOCIOUS PUBERTY DURING SUPPRESSIVE THERAPY WITH LH-RH ANALOGUE (D-TRP-6-LH-RH)
The inhibition of gonadotropin secretion in children with central precocious puberty treated with LH-RH analogues results in suppression of the pubertal development, including growth velocity. In some patients...
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Article
190 LONG TERM THERAPY OF PRECOCIOUS PUBERTY WITH THE SUPERACTIVE LH-RH ANALOGUE D-TRP-6-LH-RH
Five girls and one boy with precocious puberty have been treated for 2-4 yrs with D-TRP-6-LH-RH (0.45-1.5 mcg/kg/day s.c.). LH and FSH secretion assessed by LRH tests remained suppressed in 4 patients; in 2 “e...
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Article
Delayed puberty and hypoplastic uterus associated with hyperprolactinemia and successfully treated with bromocriptine
A 15 year-old-girl referred because of primary amenorrhea was found to have a hypoplastic uterus and persistent hyperprolactinemia (72-110 ng/ml). Pubertal development was retarded: breasts Tanner stage 3, pub...
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Article
Primary gonadal failure and precocious adrenarche in a boy with Prader-Labhart-Willi syndrome
A 7-year-old boy with Prader-Labhart-Willi syndrome who had precocious adrenarche was found to have primary gonadal failure, as evidenced by appropriate laboratory investigations: elevated basal levels of plas...
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Article
Comparison of estrogen induced breast development in girls with hyper- or hypo-gonadotrophic hypogonadism
Breast growth induced by estrogen (and progesteron) administered for 0.5-4 yrs, was evaluated in girls aged 11-22 yrs belonging to 4 clinical entities.
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Article
Parathyroid (PTH) infusion test in hypo- (HP), pseudoshypo- (PHP) and pseudopseudohypoparathyroidism (PPHP)
Ten healthy children, 3 children with HP, a child with PHP and a child with PPHP were infused with 250 U PTH over 15 min. The renal excretion of cyclic AMP, P, Ca, HCO3, Na and K was measured and compared to 28 a...
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Article
Kallman's syndrom with high set osmotic threshold (OT) and deficient thirst
A patient with Kallman's syndrom is presented, who had deficient thirst mechanism and high set OT for vasopressin secretion. Random determinations of plasma osmolality (Posm) revealed high values of 296-307 mO...
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Article
Instable osmoreceptors and deficient thirst in hypothalamic hypopituitarism
A unique abnormality of osmoreceptors is reported in a child with hypothalamic hypopituitarism. Anterior pituitary testing revealed deficiency of GH, TSH and ACTH. The clinical course was characterized by fluc...
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Article
Endcrine studies in anorexia nervosa (AN) concurrent with XO gonadal dysgenesis (GD)
Comprehensive endocrinological investigations were performed in a 15 yr old girl with XO-GD during AN and after recovery. This is the 10th report and first endocrine study of this combination. Basal parameters...
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Article
Anthropometric measurements in patients with growth hormone deficiency before treatment with human growth hormone
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Article
Prolactin deficiency, obesity and enlarged testes - a new syndrome?
An infant with progressive obesity and bulimia present from birth was first seen by us at the age of 1 year and has now been followed for 3 years. He grew consistently along the 90th percentile with slight bon...
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Article
Comparative HGH response to i.v. glucagon and i.v. arginine stimulation tests in children and adolescents
Thirty-seven children and adolescents of several diagnostic entitites (constitutional growth retardation, diabetes mellitus and pituitary insufficiency) were tested with an i.v. bolus injection of glucagon for...
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Article
LH AND FSH RESPONSE TO LH-RH IN 27 GIRLS WITH PRECOCIOUS PUBERTY
An LH-RH test was done in 27 girls with precocious puberty (PP), 26 idiopathic and one with a brain tumor, and in 47 girls with normal puberty (pubertal staging according to Tanner). In 10 girls with PP tested...
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Article
THE ADVANTAGE OF INTERMITTENT HGH THERAPY IN PATIENTS WITH ISOLATED AND COMBINED HGH DEFICIENCY
Out of 46 patients treated by an intermittent HGH regime, 5 pts. with isol. HGH deficiency (IGHD) and 5 pts. with panhypopituitarism (CGHD) are presented. HGH was administered thrice weekly, 1–3 mg/injection, ...
