Abstract
A patient with Kallman's syndrom is presented, who had deficient thirst mechanism and high set OT for vasopressin secretion. Random determinations of plasma osmolality (Posm) revealed high values of 296-307 mOsm/kg. The OT defined by the isovolemic infusion of hypertonic saline, was 296mOsm/kg. This was significantly higher than the OT of 7 normal controls, 286.6±0.9 (M±SD). He had intact volume receptors, as shown by an appropriate fall of free water clearance during dehydration, from -0.3 to -1.25/min. His pressor receptors were shown to be intact by a normal response to the hypotensive agent trimethaphane with a fall of free water clearance from 10 to 1 ml/min. and a rise of plasma ADH from < 1 to 26uU/ml. Indifference to thirst was expressed at plasma osmolality as high as 301mOsm/kg. It is suggested that deficient thirst and high set OT are additional manifestations of the hypothalamic involvement of Kallman's syndrom.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Z, H., Miller, M., Richman, R. et al. Kallman's syndrom with high set osmotic threshold (OT) and deficient thirst. Pediatr Res 15, 85 (1981). https://doi.org/10.1203/00006450-198101000-00086
Issue Date:
DOI: https://doi.org/10.1203/00006450-198101000-00086
- Springer Nature America, Inc.