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Article
LONG-TERM hGH TREATMENT OF SHORT PREPUBERTAL CHILDREN IMPROVES THEIR HEIGHT
Forty-six short children classified as familial short stature (FSS) or intrautcrinc growth retardation (1UGR) and normal GH reserve (≥ 10 ng/ml) were t recited with rhCH (Norditropin - Novo/Nordisk, 0.1 U/kg/d...
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Article
HYPERANDROGENISM AS A CAUSE OF EARLY POLYCYSTIC OVARY SYNDROME (PCOS) IN GIRLS WITH CENTRAL PRECOCIOUS PUBERTY (CPP)
Increased adrenal androgens are often observed in girls with CPP. The hyperandrogenism is not affected by the therapy with GnRh analog (GnRHA). We performed an i.v. ACTH stimulation test (0.25mg) in 42 girls w...
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Article
Growth hormone therapy in normal short children induces a transitory decrease in plasma growth hormone releasing hormone levels and in human growth hormone responsiveness to exogenous growth hormone releasing hormone
A three-month study of the effect of growth hormone (hGH) therapy (0.1 U/kg/day sc) on plasma levels of GH releasing hormone (GHRH), somatostatin and insulin-like growth factor I (IGF-I) and on the hGH respons...
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Article
87 EFFECT OF CRF 1–41 AS COMPARED TO INSULIN HYPOGLYCEMIA (ITT) ON PLASMA CORTISOL AND ACTH IN SUBJECTS WITH INTACT OR DEFECTIVE HYPOTHALAMIC-PITUITARY FUNCTIONS
Synthetic CRF 1-41 in a dose of 1 mcg/kg was administered i.v. Plasma cortisol (CO) and ACTH were determined before and at 30, 60, 90 & 120 min. Fourteen children (12M, 2F 12±4.8 yrs) were investigated includi...
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Article
40 hGH RESPONSE TO GH-RH 1–44 IN OBESITY OF VARIOUS ETIOLOGIES
Fourteen juveniles with obesity were tested with i.v. GH-RH 1-44 (1 mcg/kg). Seven had simple obesity and in the other 7 the obesity was associated with the following syndromes: Prader-Willi (n=4); Laurence Mo...
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Article
39 EFFICIENCY OF GROWTH PROMOTING ACTION OF hGH IS HIGHEST IN VERY YOUNG DEFICIENT CHILDREN
The effect of hGH treatment was studied in 21 prepubertal (12 M, 9 F) GH deficient children (14 IGHD, 7 MPHD) treated for 5 yrs. They were grouped according to age at start of therapy: Gr. A: CA 0.9-4.8, BA 1±...
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Article
Social and vocational adjustment of 38 hjgh deficent patients after termination of thearpy
Thirty eight hGH deficient patients aged from 15 to 35 yrs in whom hGH therapy was stopped upon termination of growth, were re-evaluated for their social adjustment by personal interviews. Their characteristic...
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Article
Classification of patients with GH deficiency (GHD) according to the response to GH-RH
Synthetic GH-RH-1-44 was administered in a dose of 1 mcg/1 Kg to 3 normal adolescents with short stature and to 17 patients with GHD (hGH response to ITT and clonidine < 2 ng/ml). In the normal subjects the pe...
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Article
Enhanced hGH pituitary secretion rate associated with somatomedin deficiency as manifested in Laron type dwarfism (LTD)
In 3 patients with LTD and 8 normal subjects the following parameters were determined:
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Article
Penile and testicular size in isolated GH deficiency (IGHD) and response to hGH treatment
The response of genital and gonadal growth during the first year of treatment with hGH was studied in 20 boys with IGHD (11 of hereditary origin and 9 sporadic cases). Prior to hGH treatment 13 of the 15 prepu...
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Article
Occurrence of four types of growth hormone-related dwarfism in Israeli communities
Data are presented on 121 dwarfed patients belonging to 98 Israeli families with 4 types of dwarfism related to deficiency or in activity of human growth hormone (hGH): isolated growth hormone deficiency (IGHD...
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Article
Comparison of estrogen induced breast development in girls with hyper- or hypo-gonadotrophic hypogonadism
Breast growth induced by estrogen (and progesteron) administered for 0.5-4 yrs, was evaluated in girls aged 11-22 yrs belonging to 4 clinical entities.
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Article
Evaluation of long term growth response to hGH treatment
The growth velocity (GV, cm/y) induced by hGH treatment was evaluated in 85 hGH deficient patients classified into 4 groups. Gr. A: Isolated hGH deficiency (IGHD), males, n=22; age at start of therapy (age): 0...
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Article
Thyroxine of human and bovine milk origin: possible bearing on congenital hypothyroidism
Thyroxine (T4) concentrations were measured by RIA in 89 milk samples, obtained between 3-165 days postpartum from 40 healthy euthyroid mothers. The mean milk T4 conc. in the first week postpartum was 0.4 ± 0....
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Article
Intraamniotic thyroxine (T4) effect in high risk pregnancies
Intraamniotic thyroxine (T4) effect in high risk pregnancies.
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Article
105: THIRTEEN-YEAR PERSISTENCE OF AN ADRENAL 18-OXIDATION DEFICIENCY IN TWINS
Identical male twins of consanguinoue Jewish Persian parents developed dehydration, hyponatremia, hyperkalemia and failed to thrive during the first months of life. Two siblings with similar symptoms died in i...
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Article
171: Effect of hGH lack on the insulin response to glucagon
Fourteen children with hGH deficiency (10 with isolated and 4 with multiple hormone deficiency) underwent an OGTT followed by i. v. glucagon at 180'. Seventeen of such children underwent in addition a single i...
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Article
24: Serum Sulfate Levels and Plasma hGH, in Patients with Low and Excessive hGH Secretion
Serum sulfate determination by the bariumchloranilate reagent (Bertolacini et al, Analytical Chemistry, 30, 202, 1958; was measured in 60 children with isolated GH deficiency (IGHD), panhypopituitarism, high IR-h...
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Article
Comparative HGH response to i.v. glucagon and i.v. arginine stimulation tests in children and adolescents
Thirty-seven children and adolescents of several diagnostic entitites (constitutional growth retardation, diabetes mellitus and pituitary insufficiency) were tested with an i.v. bolus injection of glucagon for...
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Article
THE ADVANTAGE OF INTERMITTENT HGH THERAPY IN PATIENTS WITH ISOLATED AND COMBINED HGH DEFICIENCY
Out of 46 patients treated by an intermittent HGH regime, 5 pts. with isol. HGH deficiency (IGHD) and 5 pts. with panhypopituitarism (CGHD) are presented. HGH was administered thrice weekly, 1–3 mg/injection, ...
