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Article
Open AccessDiffuse large B-cell lymphoma: the significance of CD8+ tumor-infiltrating lymphocytes exhaustion mediated by TIM3/Galectin-9 pathway
Overexpression of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is related to the exhaustion of CD8+ tumor-infiltrating lymphocytes (TILs) in diffuse large B-cell lymphoma (DLBCL). However, t...
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Chapter and Conference Paper
Construction of Knowledge Graph Based on Design Thinking Cultivation
Design and innovation are themes of our time, given the rapid changes in the digital information age. Consequently, the integration of design thinking as a higher order thinking skill into the curriculum is es...
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Article
Open AccessTn3-like structures co-harboring of blaCTX-M-65, blaTEM-1 and blaOXA-10 in the plasmids of two Escherichia coli ST1508 strains originating from dairy cattle in China
The purpose of this study was to determine the level of horizontal transmission of the blaCTX-M-65 gene and the role of its associated mobile genetic elements (MGEs) in the bovine-derived Escherichia coli. After ...
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Article
Open AccessSystematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma
RNASET2 has been identified as an oncogene with anti-angiogenic and immunomodulatory effects in a variety of cancers, but its function in clear cell renal cell carcinoma (ccRCC) is still not well understood.
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Article
Open AccessCT-based radiogenomic analysis dissects intratumor heterogeneity and predicts prognosis of colorectal cancer: a multi-institutional retrospective study
This study aimed to develop a radiogenomic prognostic prediction model for colorectal cancer (CRC) by investigating the biological and clinical relevance of intratumoural heterogeneity.
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Article
Open AccessLeft colic artery diameter is an important factor affecting anastomotic blood supply in sigmoid colon cancer or rectal cancer surgery: a pilot study
Anastomotic blood supply is vital to anastomotic healing. The aim of this study was to demonstrate the effect of the left colic artery (LCA) on blood supply in the anastomotic area, explore the relationship be...
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Article
In situ synthesis of Co-doped MoS2 nanosheet for enhanced mimicking peroxidase activity
To enhance the catalytic activity of two-dimensional layered materials as versatile materials, the modification of transition metal dichalcogenide nanosheets such as MoS2 by do** with heteroatoms has drawn grea...
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Article
Research on the effect of Deinococcus radiodurans transformed by dsrA-flr-2 double gene on the enrichment performance of uranium(VI)
Strong-reducing gene (dsrA) and the fluorine-resistant gene (flr-2) were cloned into D. radiodurans to prepare a recombinant Deino-dsrA-flr-2 strains. Then, the influencing factors of uranium enrichment by Deino-...
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Article
The reduction effect and mechanism of Deinococcus radiodurans transformed dsrA gene to uranyl ions
Deinococcus radiodurans (DR) is highly resistant to ionizing radiation. This study aims to convert dsrA gene into DR to construct radiation-resistant genetically engineered bacteria (Deino-dsrA) with high reducib...
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Article
Application Progress of Deinococcus radiodurans in Biological Treatment of Radioactive Uranium-Containing Wastewater
Radioactive uranium wastewater contains a large amount of radionuclide uranium and other heavy metal ions. The radioactive uranium wastewater discharged into the environment will not only pollute the natural e...
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Article
Open AccessVirulence factors and molecular characteristics of Shigella flexneri isolated from calves with diarrhea
The natural hosts of Shigella are typically humans and other primates, but it has been shown that the host range of Shigella has expanded to many animals. Although Shigella is becoming a major threat to animals, ...
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Article
Construction of Deino-flr-2 radiation-tolerant genetically engineered strain containing flr-2 fluoride-tolerant gene and its enrichment behavior for U(VI)
In order to solve the problem of lack of resistance of active microorganisms to the complex ion environment in the treatment of uranium-containing wastewater, the Deino-flr-2 radiation-resistant genetically engin...
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Article
Novel tumour–infiltrating lymphocyte-related risk stratification based by flow cytometry for patients with de novo angioimmunoblastic T cell lymphoma
Tumour-infiltrating lymphocytes (TILs) account for a large proportion of tumour microenvironment (TME) in angioimmunoblastic T cell lymphoma (AITL), and at present the significance of TIL in TME of AITL remain...
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Article
A novel magnetic functionalized m-carboxyphenyl azo calix[4]arene symmetric sulfide derivative: synthesis and application as a selective adsorbent for removal of U (VI)
A novel adsorbent magnetic functionalized m-carboxyphenyl azo calix[4]arene symmetrical sulfide derivative (Fe3O4/M-CCSSD) was fabricated by a series of simple reactions and characterized by FT-IR and SEM. The ef...
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Article
Enhanced Thermoelectric Performance of Cu3SbSe4 Doped with Alkali-Ion (Na and K)
The thermoelectric properties of alkali-ion-doped compounds Cu3Sb1−xMxSe4 (M = Na and K) prepared by mechanical alloying and spark plasma sintering compaction, are investigated systematically between 300 K and 67...
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Article
Fabrication of magnetic functionalized m-carboxyphenyl azo calix[4]arene amine oxime derivatives for highly efficient and selective adsorption of uranium (VI)
A novel material called m-carboxyphenyl azo calix[4]arene amine oxime derivatives (M-CCAOD) was synthesized by diazotization-coupling reaction and substitution reaction. Then the composite consisting of Fe3O4 and...
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Article
Open AccessN-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats
Patients with diabetes are prone to develop cardiac hypertrophy and more susceptible to myocardial ischemia–reperfusion (I/R) injury, which are concomitant with hyperglycemia-induced oxidative stress and impai...
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Article
Open AccessForkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understoo...
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Article
Open AccessTarget delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model
Folate-nanoliposomes delivery system has emerged recently as a specific and safety delivery method and gradually used as the carrier of a variety kinds of drugs including compounds, plasmids and siRNAs.
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Chapter and Conference Paper
A New Methodology for Modeling and Controlling Design Processes
Modeling of design processes is one of key issues of the management of complex product development because of its role in sustaining efficient and optimal execution of the design processes. This paper proposes...
