7 Result(s)
within
Pierre-Eric Lutz
English
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Article
Open AccessFunctional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies
In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a...
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Article
Open AccessThe basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice
While depression and chronic pain are frequently comorbid, underlying neuronal circuits and their psychopathological relevance remain poorly defined. Here we show in mice that hyperactivity of the neuronal pat...
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Article
Open AccessNon-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation
Early-life adversity (ELA) is a major predictor of psychopathology, and is thought to increase lifetime risk by epigenetically regulating the genome. Here, focusing on the lateral amygdala, a major brain site ...
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Article
Open AccessGlobal long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides
Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed...
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Article
Open AccessMedium throughput bisulfite sequencing for accurate detection of 5-methylcytosine and 5-hydroxymethylcytosine
Epigenetic modifications of DNA, such as 5-methylcytosine and 5-hydroxymethycytosine, play important roles in development and disease. Here, we present a cost-effective and versatile methodology for the analys...
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Article
Distinct Mu, Delta, and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence
Addiction is a chronic disorder involving recurring intoxication, withdrawal, and craving episodes. Esca** this vicious cycle requires maintenance of abstinence for extended periods of time and is a true cha...
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Article
Open AccessBisQC: an operational pipeline for multiplexed bisulfite sequencing
Bisulfite sequencing is the most efficient single nucleotide resolution method for analysis of methylation status at whole genome scale, but improved quality control metrics are needed to better standardize ex...
