7 Result(s)
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Article
Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach
The daily renewal of the corpus epithelium is fuelled by adult stem cells residing within tubular glands, but the identity of these stem cells remains controversial. Lgr5 marks homeostatic stem cells and ‘rese...
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Article
Organoids as an in vitro model of human development and disease
Barker and colleagues review the history and recent developments of organoid cultures derived from pluripotent stem cells and adult epithelia, and discuss how the technology can be used for basic research as w...
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Article
Ovary and fimbrial stem cells: biology, niche and cancer origins
Cyclic rupture and repair of the ovarian surface epithelium during ovulation, and repeated exposure of the fimbrial epithelium to the mechanics of follicular r...
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Article
Lgr5 marks stem/progenitor cells in ovary and tubal epithelia
The ovary surface epithelium (OSE) undergoes ovulatory tear and remodelling throughout life. Resident stem cells drive such tissue homeostasis in many adult epithelia, but their existence in the ovary has not ...
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Article
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration
Intestinal stem cells are responsible for the remarkable ability of the intestinal epithelium to efficiently renew and repair itself throughout life.
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Article
Stem cell reprogramming as a driver of basal cell carcinoma
Basal cell carcinoma has been shown to originate from activation of hedgehog signalling in interfollicular epidermal progenitor cells. Analyses of the early steps of basal cell carcinoma formation show that th...
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Article
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
Notch signalling in the intestinal crypt is modulated to drive commitment to the secretory fate. Clevers and colleagues find that cells expressing the Notch ligand DLL1 are intermediate secretory cells that ca...
