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Article
Neutralization Versus Reinforcement of Proinflammatory Cytokines to Arrest Autoimmunity in Type 1 Diabetes
As physiological pathways of intercellular communication produced by all cells, cytokines are involved in the pathogenesis of inflammatory insulitis as well as pivotal mediators of immune homeostasis. Proinfla...
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Article
Mechanisms of diabetic autoimmunity: I—the inductive interface between islets and the immune system at onset of inflammation
The mechanisms of autoimmune reactivity onset in type 1 diabetes (T1D) remain elusive despite extensive experimentation and discussion. We reconsider several key aspects of the early stages of autoimmunity at...
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Article
Mechanisms of diabetic autoimmunity: II—Is diabetes a central or peripheral disorder of effector and regulatory cells?
Two competing hypotheses aiming to explain the onset of autoimmune reactions are discussed in the context of genetic and environmental predisposition to type 1 diabetes (T1D). The first hypothesis has evolved ...
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Article
Lymphopenia is detrimental to therapeutic approaches to type 1 diabetes using regulatory T cells
One of the therapeutic approaches to type 1 diabetes (T1D) focuses on enhancement of regulatory T cell (Treg) activity, either by adoptive transfer or supplementation of supporting cytokines such as interleuki...
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Article
VEGF Induces Neuroglial Differentiation in Bone Marrow-Derived Stem Cells and Promotes Microglia Conversion Following Mobilization with GM-CSF
Evaluation of potential tropic effects of vascular endothelial growth factor (VEGF) on the incorporation and differentiation of bone-marrow-derived stem cells (BMSCs) in a murine model of anterior ischemic opt...
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Article
Immunotherapy in high-risk chemotherapy-resistant patients with metastatic solid tumors and hematological malignancies using intentionally mismatched donor lymphocytes activated with rIL-2: a phase I study
The feasibility and safety of immunotherapy mediated by intentionally mismatched rIL-2 activated killer lymphocytes (IMAK) with no prior stem cell engraftment was investigated in patients with advanced chemoth...
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Article
Graft versus neuroblastoma reaction is efficiently elicited by allogeneic bone marrow transplantation through cytolytic activity in the absence of GVHD
Continuous efforts are dedicated to develop immunotherapeutic approaches to neuroblastoma (NB), a tumor that relapses at high rates following high-dose conventional cytotoxic therapy and autologous bone marrow...
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Article
Glycolysis protects sarcolemmal membrane integrity during total ischemia in the rat heart
Experimental evidence indicates that ischemic glycolysis improves myocardial tolerance to low flow ischemia and anoxia, and cellular membrane disruption signals and/or causes transition to irreversible ischem...
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Article
Is cytotoxic cellular edema real?
The objective of this study was to determine the effect of calcium on water homeostasis in cardiac muscle and whether cytotoxic edema is involved in ischemic-reperfusion injury. Cellular water was quantified b...
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Chapter
Some Light on the Controversy about the Effects of the Shift to Daylight Saving Time on Road Accidents
It was assumed that the shift from standard time to a new time (Daylight Saving Time — DST), by inducing a sleep deprivation of one hour, would induce more sleepiness and by these more road accidents (RA). How...
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Chapter
Two-Dimensional 31P-1H Correlation Spectroscopy in Intact Organs and Their Extracts
2D 31P-1H correlation spectroscopy is a useful technique for the assignment of 31P-NMR resonances. It allows the separation of overlap** 31P peaks by spreading them in the 1H dimension and gives the chemical sh...
