36 Result(s)

Article

Preimplantation factor (PIF) analog prevents type I diabetes mellitus (TIDM) development by preserving pancreatic function in NOD mice

Preimplantation factor (PIF) is a novel embryo-secreted immunomodulatory peptide. Its synthetic analog (sPIF) modulates maternal immunity without suppression. There is an urgent need to develop agents that cou...

Lola Weiss, Steve Bernstein, Richard Jones, Ravi Amunugama, David Krizman… in Endocrine (2011)

Article

Immunotherapy in high-risk chemotherapy-resistant patients with metastatic solid tumors and hematological malignancies using intentionally mismatched donor lymphocytes activated with rIL-2: a phase I study

The feasibility and safety of immunotherapy mediated by intentionally mismatched rIL-2 activated killer lymphocytes (IMAK) with no prior stem cell engraftment was investigated in patients with advanced chemoth...

Shimon Slavin, Aliza Ackerstein, Reuven Or… in Cancer Immunology, Immunotherapy (2010)

Article

The oxidative status of blood cells in a murine model of graft-versus-host disease

We studied the oxidative status of red and white blood cells during the development of graft vs host disease (GVHD) as well as the effects of treatment with antioxidants, both in vitro and in vivo. (BALB/c X C...

Johnny Amer, Lola Weiss, Shoshana Reich, Michael Y. Shapira… in Annals of Hematology (2007)

Article

Interleukin 2 regulation following semi-allogeneic bone marrow transplantation in mice

Success of allogeneic and autologous bone marrow transplantation (BMT) is hampered by susceptibility to infection during the first two post-treatment years. Further, in treating malignant diseases, impaired an...

Ali Abdul-Hai, Arie Ben-Yehuda, Haya Galsky… in Cancer Immunology, Immunotherapy (2006)

Article

Mycophenolate mofetil does not suppress the graft-versus-leukemia effect or the activity of lymphokine-activated killer (LAK) cells in a murine model

Background: Graft-versus-leukemia (GVL) effect is an essential component in the course of allogeneic stem cell transplantation (SCT). However, both prevention and treatment of established graft-versus-host dis...

Michael Y. Shapira, Ester Hirshfeld, Lola Weiss… in Cancer Immunology, Immunotherapy (2005)

Article

Allogeneic stem cell transplantation for the treatment of diseases associated with a deficiency in bone marrow products

Our understanding of the pathophysiology of hematopoietic failure associated syndromes led to the developmental of potentially curative procedures for the treatment of many diseases including Severe aplastic a...

Reuven Or, Memet Aker, Michael Yechiel Shapira… in Springer Seminars in Immunopathology (2004)

Article

Introduction

Shimon Slavin in Springer Seminars in Immunopathology (2004)

Article

Transplantation of hematopoietic stem cells for induction of unresponsiveness to organ allografts

Although it has been recognized since the early days of Owen and Medawar that engraftment of donor stem cells, induced in utero spontaneously or intentionally neonatally, results in life-long unresponsiveness ...

Tatyana Prigozhina, Shimon Slavin in Springer Seminars in Immunopathology (2004)

Article

Non-myeloablative stem cell transplantation for autoimmune diseases

Treatment of life-threatening autoimmune diseases in animal models with induced or spontaneous autoimmune diseases can be accomplished by a 2-step procedure involving elimination of self-reactive lymphocytes w...

Richard K. Burt, Larissa Verda, Yu Oyama… in Springer Seminars in Immunopathology (2004)

Article

Immunotherapy of murine leukemia following non-myeloablative conditioning with naïve or G-CSF mobilized blood or bone marrow stem cells

Allogeneic stem cell transplantation (SCT) is the treatment of choice for a large number of hematologic malignancies. Its major advantage over conventional chemotherapy lies in the graft-versus-leukemia (GVL) ...

Lola Weiss, Reuven Or, Shimon Slavin, Ella Naparstek… in Cancer Immunology, Immunotherapy (2004)

Article

Graft-versus-Host Disease, the Graft-versus-Leukemia Effect, and Mixed Chimerism following Nonmyeloablative Stem Cell Transplantation

Allogeneic bone marrow or blood stem cell transplantation represents an important therapeutic tool for the treatment of otherwise incurable cancer and a large spectrum of nonmalignant diseases. Until recently,...

Shimon Slavin in International Journal of Hematology (2003)

Article

Linomide administration following bone marrow transplantation in mice

The effect of linomide, an immunomodulatory drug, on natural killer (NK) cells and T cell-dependent immune responses following syngeneic or allogeneic bone marrow transplantation (BMT) was investigated in BALB...

Lola Weiss, Ali Abdul-Hai, Yoel Shufaro… in Cancer Immunology, Immunotherapy (2002)

Article

Treatment of Leukemia by Alloreactive Lymphocytes and Nonmyeloablative Stem Cell Transplantation

Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeutic tool for treatment of otherwise incurable malignant and nonmalignant diseases, especially acute and chronic l...

Shimon Slavin, Arnon Nagler, Michael Y. Shapira… in Journal of Clinical Immunology (2002)

Article

Maternal-fetal relationship, natural chimerism and bilateral transplantation tolerance as the basis for non-myeloablative stem cell transplantation

Bone marrow transplantation (BMT) which represents an important clinical tool for treatment of patients with a wide variety of malignant and non-malignant diseases, however, the procedure is associated with pr...

Shimon Slavin in International Journal of Hematology (2002)

Article

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?

Hematopoietic stem cells (HSCs) are the earliest cells of the immune system, giving rise to B and T lymphocytes, monocytes, tissue macrophages, and dendritic cells. In animal models, adoptive transfer of HSCs,...

Richard K. Burt, Shimon Slavin, William H. Burns… in International Journal of Hematology (2002)