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Article
Open AccessPHGDH: a novel therapeutic target in cancer
Serine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal p...
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Article
Improvement of tensile strength and anti-oxidation property of graphite electrode for electric arc furnace through heterogenization of binder pitch
This study involved the heterogenization of a binder pitch (BP) using a small amount of nanocarbon to improve physical properties of the resulting graphite electrode (GE). Heterogenization was carried out by a...
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Article
Investigation of Carburization and Melting Behavior of Fully Reduced LRI and IOS on Coke Substrates
In the course of develo** hydrogen-enriched blast furnace ironmaking operation, the carburization and melting behavior of the fully reduced low-reduced iron (LRI) and the iron ore sinter (IOS) on the coke su...
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Article
Safety of applying influenza-antigen-coated microneedles to rat skin and the antigen specific immune response in vivo
Technological advancements and innovations in the use of microneedles for medicinal purposes are constantly emerging. To promote the marketing of microneedles, the safety of microneedle systems during applicat...
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Article
Correction: Rapid multi-material joining via flow drill screw process: experiment and FE analysis using the coupled Eulerian‒Lagrangian method
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Article
Open AccessCharacterization of Formed TRIP1180 Steel Sheet Surface After Stam** with PVD-Coated Tools
The wear tests are conducted on bending punches deposited with PVD CrN and AlTiCrN coatings using the newly proposed progressive die. Then, the surface quality of the formed product is characterized through th...
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Article
Open AccessBRCA1 mutation promotes sprouting angiogenesis in inflammatory cancer-associated fibroblast of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with inferior outcomes owing to its low treatment response and high invasiveness. Based on abundant cancer-associated fibroblasts (CA...
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Chapter and Conference Paper
On the Development of a Motor Driver for Physical Human-Robot Interactions
This paper presents a novel motor driver design suitable for physical human-robot interactions. Unlike traditional motor drivers for motion control, our proposed motor driver design for interaction controls is...
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Article
Considerations related to the in-use stability of sterile pharmaceutical dosage forms
It is essential to ensure the in-use stability of sterile preparations because they may be vulnerable to microbial contamination during the opening and preparation process. Although some regulatory agencies pr...
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Article
A Stepped Mesh Host for Lithium Metal Batteries Inspired by Transmission Electron Microscopy Sampling Grids
With the growing demand for high-energy-density rechargeable batteries, lithium metal anodes have reemerged as a promising alternative to conventional graphite anodes in lithium-ion batteries. Lithium metal bo...
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Article
Fractional Helly Theorem for Cartesian Products of Convex Sets
Helly’s theorem and its variants show that for a family of convex sets in Euclidean space, local intersection patterns influence global intersection patterns. A classical result of Eckhoff in 1988 provided an ...
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Article
Targeting isoforms of RON kinase (MST1R) drives antitumor efficacy
Recepteur d’origine nantais (RON, MST1R) is a single-span transmembrane receptor tyrosine kinase (RTK) aberrantly expressed in numerous cancers, including various solid tumors. How naturally occurring splicing...
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Article
Rapid multi-material joining via flow drill screw process: experiment and FE analysis using the coupled Eulerian‒Lagrangian method
This paper is concerned with experiments and finite element (FE) simulations using the coupled Eulerian‒Lagrangian (CEL) method for multi-material joining by the flow drill screw (FDS) process. The FDS joining...
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Article
Open AccessAn on-demand bioresorbable neurostimulator
Bioresorbable bioelectronics, with their natural degradation properties, hold significant potential to eliminate the need for surgical removal. Despite notable achievements, two major challenges hinder their p...
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Article
Open AccessLeray Numbers of Tolerance Complexes
Let K be a simplicial complex on vertex set V. K is called d-Leray if the homology groups of any induced subcomplex of K are trivial in dimensions d and higher. K is called d-collapsible if it can be reduced to t...
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Article
Open AccessCo-inhibition of glutaminolysis and one-carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer
Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors with an extremely poor prognosis. Based on the several biological features related to glutamine metabolism in ATC, we hypothesized glutamino...
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Article
Open AccessElectromagnetic drag forces between HTS magnet and tube infrastructure for hyperloop
Maglevs are typically accelerated using electromagnetic propulsion and levitation. High-temperature superconducting (HTS) magnets along with electrodynamic suspension (EDS) and linear synchronous motors are on...
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Article
Evaluating Implementation Costs of an Enhanced Recovery After Surgery (ERAS) Protocol in Colorectal Surgery: A Systematic Review
Enhanced recovery after surgery (ERAS) protocols have been well documented in the current literature to improve healthcare outcomes by decreasing length of stay, resource utilization, and morbidity without inc...
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Article
An economically advantageous amorphous solid dispersion of the fixed combination of lopinavir and ritonavir
Solid dispersion strategies have recently been used to increase the solubility and bioavailability of poorly soluble drugs. Among these various strategies for solid dispersion, the method using polymers and ad...
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Article
Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers
Ticagrelor (TCG), an antiplatelet agent, has low solubility and permeability; thus, there are many trials to apply the pharmaceutical technology for the enhancement of TCG solubility and permeability. Herein, ...
