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Article
Targeting isoforms of RON kinase (MST1R) drives antitumor efficacy
Recepteur d’origine nantais (RON, MST1R) is a single-span transmembrane receptor tyrosine kinase (RTK) aberrantly expressed in numerous cancers, including various solid tumors. How naturally occurring splicing...
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Article
TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
Colorectal cancer (CRC) is one of the highest mortality rates worldwide, and various studies reported to the occurrence of CRC. In particular, the Wnt/β-catenin pathway is known to be a major factor in the pro...
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Article
NME1 functions as a metastasis suppressor in pancreatic cancer
A known metastasis suppressor gene, NME1 (Nm23), downregulated in melanoma, breast cancer, and other cancers, suppresses migration and invasion of tumor cells. However, in pancreatic cancer (PC), one of the commo...
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Article
DGG-300273, a novel WNT/β-catenin inhibitor, induces apoptotic cell death by activating ROS-BIM signaling in a Wnt-dependent manner in colon cancer cells
Dysregulated Wnt signaling is associated with malignant oncogenic transformation, especially in colon cancer. Recently, numerous drugs have been developed based on tumorigenesis biomarkers, thus having high po...
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Article
Role of p53 in transcriptional repression of SVCT2
SVCT2, Sodium-dependent Vitamin C Transporter 2, uniquely transports ascorbic acid (also known as vitamin C and ascorbate) into all types of cells. Vitamin C is an essential nutrient that must be obtained thro...
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Article
Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells
Inhibitor of apoptosis proteins (IAPs) are overexpressed in the majority of cancers and prevent apoptosis by inhibiting caspases. IAPs have therefore attracted considerable attention as potential targets for a...
