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Article
Open AccessSingle-cell RNA-seq reveals the effects of the FecB mutation on the transcriptome profile in ovine cumulus cells
Genetic variations in the ovine ovulation rate, which are associated with the FecB mutation, provide useful models by which to explore the mechanisms regulating the development of mammalian antral follicles. In o...
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Article
Open AccessKey mRNAs and lncRNAs of pituitary that affect the reproduction of FecB + + small tail han sheep
The pituitary directly regulates the reproductive process through follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Transcriptomic research on the pituitaries of ewes with different FecB (fecundity...
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Article
Open AccessTranscriptome study digs out BMP2 involved in adipogenesis in sheep tails
Hu sheep and Tibetan sheep in China are characterized by fat tails and thin tails, respectively. Several transcriptomes have been conducted in different sheep breeds to identify the differentially expressed ge...
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Article
Open AccessmiRNA-mRNA analysis of sheep adrenal glands reveals the network regulating reproduction
The adrenal gland participates in the process of sheep reproduction. MicroRNAs (miRNAs), endogenous small noncoding RNAs, regulate gene expression at the posttranscriptional level. However, the miRNA-mRNA netw...
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Article
Open AccessIntegrated analyses of miRNA-mRNA expression profiles of ovaries reveal the crucial interaction networks that regulate the prolificacy of goats in the follicular phase
Litter size is an important index of mammalian prolificacy and is determined by the ovulation rate. The ovary is a crucial organ for mammalian reproduction and is associated with follicular development, matura...
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Article
Open AccessExpression, structure and function analysis of the sperm-oocyte fusion genes Juno and Izumo1 in sheep (Ovis aries)
JUNO and IZUMO1 are the first receptor-ligand protein pairs discovered to be essential for sperm-oocyte fusion; their interaction is indispensable for fertilization.
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Article
Open AccessPineal gland transcriptomic profiling reveals the differential regulation of lncRNA and mRNA related to prolificacy in STH sheep with two FecB genotypes
Long noncoding RNA (lncRNA) has been identified as important regulator in hypothalamic-pituitary-ovarian axis associated with sheep prolificacy. However, little is known of their expression pattern and potenti...
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Article
Open AccessExploring the roles of fecundity-related long non-coding RNAs and mRNAs in the adrenal glands of small-tailed Han Sheep
Long non-coding RNAs (lncRNAs) can play important roles in uterine and ovarian functions. However, little researches have been done on the role of lncRNAs in the adrenal gland of sheep. Herein, RNA sequencing ...
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Article
Open AccessTrend analysis of the role of circular RNA in goat skeletal muscle development
Circular RNA (circRNA) is produced during the splicing of mRNA (in addition to linear splicing) and is part of the gene regulatory network. The temporal expression patterns the different developmental stages w...
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Article
Open AccessComparative analysis of differentially expressed genes between the ovaries from pregnant and nonpregnant goats using RNA-Seq
A multitude of genes tightly regulate ovarian follicular development and hormone secretion. These complex and coordinated biological processes are altered during pregnancy. In order to further understand the r...
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Article
Open AccessRapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails
Sheep have developed the ability to store fat in their tails, which is a unique way of reserving energy to survive a harsh environment. However, the mechanism underlying this adaptive trait remains largely uns...
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Article
Open AccessInvestigation of hypoxia networks in ovarian cancer via bioinformatics analysis
Ovarian cancer is a leading cause of the death from gynecologic malignancies. Hypoxia is closely related to the malignant growth of cells. However, the molecular mechanism of hypoxia-regulated ovarian cancer c...
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Article
Open AccessThe potential regulatory mechanisms of the gonadotropin-releasing hormone in gonadotropin transcriptions identified with bioinformatics analyses
The regulation of gonadotropin synthesis and release by gonadotropinreleasing hormone (GnRH) plays an essential role in the neuroendocrine control of reproduction. However, the mechanisms underlying gonadotro...
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Article
Open AccessComparative profiling of differentially expressed microRNAs between the follicular and luteal phases ovaries of goats
To explore if the regulation at post-transcriptional level of follicular phase (Fols) to luteal phase (Luts) transition occurs in the ovaries of Anhuai goats, the differentially expressed microRNAs (miRNAs) of...
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Article
Polymorphism of Prophet of Pit-1 gene and its relationship with litter size of Small Tail Han sheep
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Article
Open AccessCharacterization and comparative profiling of ovarian microRNAs during ovine anestrus and the breeding season
Seasonal estrus is a critical limiting factor of animal fecundity, and it involves changes in both ovarian biology and hormone secretion in different seasons. Previous studies indicate that two classes of smal...
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Article
Analysis on cDNA sequence, alternative splicing and polymorphisms associated with timing of puberty of Lin28B gene in goats
Recently, variations in or near Lin28B gene were reported to be associated with timing of human puberty by genome-wide association studies. There have been no reports on that in other mammals. In the present stud...
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Article
Polymorphisms of KiSS-1 and GPR54 genes and their relationships with litter size in sheep
The KiSS-1 and GPR54 genes were studied as candidate genes for the prolificacy in sheep. Four pairs of primers were designed to detect single nucleotide polymorphisms of exon 1 of KiSS-1 gene and exon 1, exon 2 a...
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Article
Molecular-based environmental risk assessment of three varieties of genetically engineered cows
The development of animal biotechnology has led to an increase in attention to biosafety issues. Here we evaluated the impact of genetically engineered cows on the environment. The probability of horizontal ge...
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Article
Biomedical soft contact-lens sensor for in situ ocular biomonitoring of tear contents
A soft contact-lens biosensor (SCL-biosensor) for novel non-invasive biomonitoring of tear fluids was fabricated and tested. Wearing a biosensor on eye enabled the in situ monitoring of tear contents. The biosens...
