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Open AccessEfficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 100-Week Results from the Phase 3 KEEPsAKE 1 Randomized Clinical Trial
Patients with psoriatic arthritis (PsA) require treatment providing durable long-term efficacy in different disease domains as well as safety. We present 100-week efficacy and safety results of risankizumab in...
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Open AccessDe novo generation of multi-target compounds using deep generative chemistry
Polypharmacology drugs—compounds that inhibit multiple proteins—have many applications but are difficult to design. To address this challenge we have developed POLYGON, an approach to polypharmacology based on...
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Article
Open AccessEfferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury
Efferocytosis is a process that removes apoptotic cells and cellular debris. Clearance of these cells alleviates neuroinflammation, prevents the release of inflammatory molecules, and promotes the production o...
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Open AccessLoss of spines in the prelimbic cortex is detrimental to working memory in mice with early-life adversity
Adverse experiences in early life can shape neuronal structures and synaptic function in multiple brain regions, leading to deficits of distinct cognitive functions later in life. Focusing on the pyramidal cel...
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Open AccessA non-genetic engineering platform for rapidly generating and expanding cancer-specific armed T cells
Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. However, the commercial production of cancer-specific T cells is often hampered by laborious cell cul...
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Article
Desired Qualities of Endovascular Tools and Barriers to Treating Medium Vessel Occlusion MeVO
Endovascular treatment (EVT) for stroke due to medium vessel occlusion (MeVO) can be technically challenging and specific endovascular tools are needed to safely and effectively recanalize these relatively sma...
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Article
Comparing the effect of virtual and in-person instruction on students’ performance in a design for additive manufacturing learning activity
The goal of this work is to compare the outcome of a design for additive manufacturing (DfAM) heuristics lesson conducted in a virtual learning environment to the same in an in-person learning environment. Pri...
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Optimal Staged Reopening Schedule Based on ICU Capacity: A Model-Informed Strategy
Reopening plans and strategies remain to be a top priority issue, post a pandemic wave, for economic recovery with a relatively safe community. We use a transmission dynamics model, parameterized through model...
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Article
A multi-scale map of cell structure fusing protein images and interactions
The cell is a multi-scale structure with modular organization across at least four orders of magnitude1. Two central approaches for map** this structure—protein fluorescent imaging and protein biophysical assoc...
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Publisher Correction: Voices of biotech leaders
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Author Correction: Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
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Angiotensin II blockers improve cardiac coronary flow under hemodynamic pressure overload
Coronary flow velocity (CFV) is reduced in pathologic cardiac hypertrophy. This functional reduction is linked to adverse cardiac remodeling, hypertension and fibrosis, and angiotensin II (AngII) is a key mole...
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Voices of biotech leaders
Nature Biotechnology asks a selection of leaders from across biotech to look at the future of the sector and make some predictions for the coming years.
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Endoscopic Submucosal Dissection for Upper Gastrointestinal Neoplasia—a North American Perspective
Organ-sparing endoscopic submucosal dissection (ESD) is an acceptable treatment strategy for superficial neoplastic lesions of the esophagus and stomach. The adoption of this technique has lagged in North Amer...
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Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice
Cancer cachexia is a highly prevalent condition associated with poor quality of life and reduced survival1. Tumor-induced perturbations in the endocrine, immune and nervous systems drive anorexia and catabolic ch...
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Privacy Concerns About Personal Health Information and Fear of Unintended Use of Biospecimens Impact Donations by African American Patients
Biospecimen donation is essential for studies of cancer prevention, early detection, and treatment. Donations from minority groups, for whom the cancer burden is high, are infrequent and inadequate for researc...
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An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia
Aggressive myeloid leukemias such as blast crisis chronic myeloid leukemia and acute myeloid leukemia remain highly lethal. Here we report a genome-wide in vivo CRISPR screen to identify new dependencies in th...
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Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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GDF15 mediates the effects of metformin on body weight and energy balance
Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk1,2. More than 60% of this effect is attributable to the ability of metformin to lo...
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Open AccessPeripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage
The continuum of pro- and anti-inflammatory response elicited by traumatic brain injury (TBI) is suggested to play a key role in the outcome of TBI; however, the underlying mechanisms remain ill -defined.
