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Article
Author Correction: Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
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Article
Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques
The transplantation of pancreatic islet cells could restore glycaemic control in patients with type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic control in rodent models of...
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Article
Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates
Host recognition and immune-mediated foreign body response to biomaterials can compromise the performance of implanted medical devices. To identify key cell and cytokine targets, here we perform in-depth syste...
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Article
Correction: Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
Nat. Biotechnol. 34, 345–352 (2016); published online 29 January 2016; corrected after print 18 April 2016 In the version of this article initially published, one author, Adam C. Graham, his affiliation, and h...
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Article
Correction: Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice
Nat. Med.; doi:10.1038/nm.4030; corrected online 18 February 2016 In the version of this article initially published online, the authors omitted acknowledgment recognizing the histology core of the Harvard Ste...
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Article
Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice
When encapsulated with alginate derivatives that resist the foreign-body response, human embryonic stem cell–derived beta cells restore long-term normoglycemia in immunocompetent mice without the need for immu...
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Article
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates
In vivo screening of a large combinatorial library of alginates identifies materials that elicit a substantially reduced foreign body response.
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Article
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocom...
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Article
Non-viral vectors for gene-based therapy
Synthetic delivery vectors have the potential to address many of the limitations of viral vectors, particularly with respect to safety.
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Article
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
One of the most significant challenges in the development of clinically viable delivery systems for RNA interference therapeutics is to understand how molecular structures influence delivery efficacy. Here, we...
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Protocol
Detecting Protein–Small Molecule Interactions Using Fluorous Small-Molecule Microarrays
General binding assays involving microarrays of small molecules can be used to identify small molecule ligands for nearly any protein, even in the absence of knowledge about protein structure or function. Seve...
