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Article
Open AccessImpact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predi...
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Article
Open AccessThe role of international education on public diplomacy: the case of Kosovo International Summer Academy
Through international education programs such as the Kosovo International Summer Academy (KSA), countries aim to change their image, influence, and shift the perception and attitudes of international students ...
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Article
Open AccessNeutralization, effector function and immune imprinting of Omicron variants
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain1 (RBD) of the spike protein. The effects of these mutations on viral infection and transmis...
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Article
Open AccessAuthor Correction: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry
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Article
Open AccessThe incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets
The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) mediate insulin responses that are proportionate to nutrient intake to facilitate glucose tolerance1. The GLP-1...
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Article
Open AccessA pan-influenza antibody inhibiting neuraminidase via receptor mimicry
Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent lower respiratory tract infections. Current influenza vaccines elicit antibodies predominantly to the hi...
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Article
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness ...
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Article
Open AccessATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development
Targeting mitochondrial oncoproteins presents a new concept in the development of effective cancer therapeutics. ATAD3A is a nuclear-encoded mitochondrial enzyme contributing to mitochondrial dynamics, cholest...
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Article
Endoscopic Submucosal Dissection for Upper Gastrointestinal Neoplasia—a North American Perspective
Organ-sparing endoscopic submucosal dissection (ESD) is an acceptable treatment strategy for superficial neoplastic lesions of the esophagus and stomach. The adoption of this technique has lagged in North Amer...
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Article
MHC-II neoantigens shape tumour immunity and response to immunotherapy
The ability of the immune system to eliminate and shape the immunogenicity of tumours defines the process of cancer immunoediting1. Immunotherapies such as those that target immune checkpoint molecules can be use...
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Article
Open AccessMolecular characterization of invasive meningococcal isolates in Burkina Faso as the relative importance of serogroups X and W increases, 2008–2012
Neisseria meningitidis serogroup A disease in Burkina Faso has greatly decreased following introduction of a meningococcal A conjugate vaccine in 2010, yet other serogroups continue to pose a risk of life-threate...
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Article
PEDOT:PSS nano-gels for highly electrically conductive silver/epoxy composite adhesives
In this work, we report a methanol-facilitated approach to directly use aqueous Poly(3,4-ethylenedioxythiophene):Poly(styrene sulfonate) (PEDOT:PSS) in the silver/epoxy composites for preparation of highly ele...
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Article
Evolution of seismic risk management for insurance over the past 30 years
During the past 30 years, there has been spectacular growth in the use of risk analysis and risk management tools developed by engineers in the financial and insurance sectors. The insurance, the reinsurance, ...
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Article
Open AccessMechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation
Alterations in the strength of excitatory synapses in the hippocampus is believed to serve a vital function in the storage and recall of new information in the mammalian brain. These alterations involve the re...
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Article
Open AccessEngaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus
Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue...
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Building an Adaptation Tool for Visualizing the Coastal Impacts of Climate Change on Prince Edward Island, Canada
A quantitative risk assessment of Prince Edward Island’s coastal residences (homes, cottages), safety and security infrastructure (roads, bridges, water treatment plants, hospitals, fire departments, etc.) and...
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Chapter
Enhancement and Recovery in Atomic Force Microscopy Images
Atomic force microscopy (AFM) images have become increasingly useful in the study of biological, chemical, and physical processes at the atomic level. The acquisition of AFM images takes more time than the acq...
