52 Result(s)
within
Mervyn Singer
Anesthesiology
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Article
Diagnosing sepsis: where we’re at and where we’re going
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Article
2030: The need for microbiologists and antimicrobial stewardship teams will still remain paramount. Author’s reply
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Article
2030: will we still need our microbiologist?
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Article
Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice?
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Article
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered as indicators of either infection or dysregulated ...
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Article
Management of diabetic ketoacidosis
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Article
Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity
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Article
High oxygen level in traumatic brain injury patients. Never ending story?
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Article
Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures
Early accurate diagnosis of infection ± organ dysfunction (sepsis) remains a major challenge in clinical practice. Utilizing effective biomarkers to identify infection and impending organ dysfunction before th...
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Article
The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute the simple solution. Author's reply
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Article
Challenging management dogma where evidence is non-existent, weak or outdated
Medical practice is dogged by dogma. A conclusive evidence base is lacking for many aspects of patient management. Clinicians, therefore, rely upon engrained treatment strategies as the dogma seems to work, or...
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Article
“L'histoire se répète”, one size does not fit all. Author’s reply
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Article
Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions
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Article
Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials
Interleukin-6 (IL-6) levels discriminate between patients with mild and severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a systematic review, meta-analysis, trial sequen...
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Article
Open AccessCurrent use of inotropes in circulatory shock
Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope thera...
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Article
Steroids in ARDS: more light is being shed
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Article
Do critical care patients hibernate? Theoretical support for less is more
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Article
Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial
Myocardial dysfunction is common in sepsis but optimal treatment strategies are unclear. The inodilator, levosimendan was suggested as a possible therapy; however, the levosimendan to prevent acute organ dysfu...
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Article
Open AccessCurrent use of vasopressors in septic shock
Vasopressors are commonly applied to restore and maintain blood pressure in patients with sepsis. We aimed to evaluate the current practice and therapeutic goals regarding vasopressor use in septic shock as a ...
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Chapter
Mitochondrial Function
While markers of global oxygen delivery are readily measurable at the bedside, the crucial question is whether this is sufficient for the cells to produce adequate energy substrate (ATP) to enable metabolism t...
