131 Result(s)

Article

Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis

The Sequential Organ Failure Assessment (SOFA) score is an important tool in diagnosing sepsis and quantifying organ dysfunction. However, despite emerging evidence of differences in sepsis pathophysiology bet...

Tobias Zimmermann, Philip Kaufmann, Simon A. Amacher, Raoul Sutter… in Critical Care (2024)

Article

Diagnosing sepsis: where we’re at and where we’re going

Tobias Zimmermann, David Brealey, Mervyn Singer in Intensive Care Medicine (2024)

Article

Immunophenoty** patients with sepsis and underlying haematological malignancy reveals defects in monocyte and lymphocyte function

Timothy Arthur Chandos Snow, Aimee Serisier… in Intensive Care Medicine Experimental (2024)

Article

Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest

Tobias Zimmermann, Pedro Lopez-Ayala, Mervyn Singer in Critical Care (2023)

Article

The immunomodulating activity of trimodulin (polyvalent IgM, IgA, IgG solution): a post hoc analysis of the phase II CIGMA trial

The phase II CIGMA trial performed in 160 patients with severe community-acquired pneumonia (sCAP) found treatment with trimodulin (human polyvalent immunoglobulin [Ig]: ~ 23% IgM, ~ 21% IgA, ~ 56% IgG) was as...

Mervyn Singer, Antoni Torres, Corina C. Heinz, Sabrina Weißmüller… in Critical Care (2023)

Article

2030: The need for microbiologists and antimicrobial stewardship teams will still remain paramount. Author’s reply

Ines Lakbar, Mervyn Singer, Marc Leone in Intensive Care Medicine (2023)

Article

2030: will we still need our microbiologist?

Ines Lakbar, Mervyn Singer, Marc Leone in Intensive Care Medicine (2023)

Article

Real-world inter-observer variability of the sequential organ failure assessment (SOFA) score in intensive care medicine: the time has come for an update: authors’ reply

Rui Moreno, Andrew Rhodes, Mervyn Singer, Jean-Louis Vincent in Critical Care (2023)

Article

Trials on oxygen targets in the critically ill patients: do they change our knowledge and practice?

Massimo Girardis, Angelique M. E. de Man, Mervyn Singer in Intensive Care Medicine (2023)

Article

Creating complex protocells and prototissues using simple DNA building blocks

Building synthetic protocells and prototissues hinges on the formation of biomimetic skeletal frameworks. Recreating the complexity of cytoskeletal and exoskeletal fibers, with their widely varying dimensions,...

Nishkantha Arulkumaran, Mervyn Singer, Stefan Howorka… in Nature Communications (2023)

Article

How to use biomarkers of infection or sepsis at the bedside: guide to clinicians

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered as indicators of either infection or dysregulated ...

Pedro Póvoa, Luís Coelho, Felipe Dal-Pizzol, Ricard Ferrer… in Intensive Care Medicine (2023)

Article

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients. Changes in clinica...

Rui Moreno, Andrew Rhodes, Lise Piquilloud, Glenn Hernandez, Jukka Takala… in Critical Care (2023)

Article

Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity

Puja Mehta, Ivan O. Rosas, Mervyn Singer in Intensive Care Medicine (2022)

Article

High oxygen level in traumatic brain injury patients. Never ending story?

Karim Asehnoune, Fabio S. Taccone, Mervyn Singer in Intensive Care Medicine (2022)

Article

Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients

Sedative agents may variably impact the stress response. Dexmedetomidine is a sympatholytic alpha₂-adrenergic agonist mainly used as a second-line sedative agent in mechanically ventilated patients. We hypothesis...

John P. R. Moore, Yahya Shehabi, Michael C. Reade, Michael Bailey… in Critical Care (2022)

Article

Combining pathogen and host metagenomics for a better sepsis diagnostic

Combining simultaneous host and pathogen metagenomic profiles in a cohort of hospitalized and critically ill patients allows for more accurate diagnosis of sepsis.

Vanya Gant, Mervyn Singer in Nature Microbiology (2022)

Article

Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures

Early accurate diagnosis of infection ± organ dysfunction (sepsis) remains a major challenge in clinical practice. Utilizing effective biomarkers to identify infection and impending organ dysfunction before th...

Roman A. Lukaszewski, Helen E. Jones, Vivian H. Gersuk… in Intensive Care Medicine (2022)

Article

Clarithromycin as an immunomodulator in sepsis: still a (IN)CLASS act

Timothy Arthur Chandos Snow, Antonio Cesar, Mervyn Singer… in Critical Care (2022)

Article

The challenge of pharmacological thromboprophylaxis in ICU patients: anti-FXa activity does not constitute the simple solution. Author's reply

Daniel A. Hofmaenner, Mervyn Singer in Intensive Care Medicine (2022)