16 Result(s)

Article

Immunophenoty** patients with sepsis and underlying haematological malignancy reveals defects in monocyte and lymphocyte function

Timothy Arthur Chandos Snow, Aimee Serisier… in Intensive Care Medicine Experimental (2024)

Article

Biological sex is associated with heterogeneous responses to IL-6 receptor inhibitor treatment in COVID-19—A retrospective cohort study

COVID-19 is associated with higher inflammatory markers, illness severity and mortality in males compared to females. Differences in immune responses to COVID-19 may underpin sex- specific outcome differences....

Dan F. Stein, Conor Foley, Matt Byott, Eleni Nastouli, Gareth Ambler… in Scientific Reports (2023)

Article

Creating complex protocells and prototissues using simple DNA building blocks

Building synthetic protocells and prototissues hinges on the formation of biomimetic skeletal frameworks. Recreating the complexity of cytoskeletal and exoskeletal fibers, with their widely varying dimensions,...

Nishkantha Arulkumaran, Mervyn Singer, Stefan Howorka… in Nature Communications (2023)

Article

Clarithromycin as an immunomodulator in sepsis: still a (IN)CLASS act

Timothy Arthur Chandos Snow, Antonio Cesar, Mervyn Singer… in Critical Care (2022)

Article

Correction to: Palliative care interventions in intensive care unit patients

Victoria Metaxa, Despina Anagnostou, Savvas Vlachos… in Intensive Care Medicine (2022)

Article

“L'histoire se répète”, one size does not fit all. Author’s reply

Timothy Arthur Chandos Snow, Naveed Saleem, Mervyn Singer… in Intensive Care Medicine (2021)

Article

Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials

Interleukin-6 (IL-6) levels discriminate between patients with mild and severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a systematic review, meta-analysis, trial sequen...

Timothy Arthur Chandos Snow, Naveed Saleem, Gareth Ambler… in Intensive Care Medicine (2021)

Article

Steroids in ARDS: more light is being shed

Nishkantha Arulkumaran, Timothy Arthur Chandos Snow… in Intensive Care Medicine (2020)

Article

Antimicrobial-associated harm in critical care: a narrative review

The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents. Antim...

Nishkantha Arulkumaran, Matthew Routledge, Sanmarié Schlebusch… in Intensive Care Medicine (2020)

Article

Palliative care interventions in intensive care unit patients – a systematic review protocol

Even though data suggest that palliative care (PC) improves patient quality of life, caregiver burden, cost, and intensive care unit (ICU) length of stay, integration of PC in the ICU is far from being univers...

Victoria Metaxa, Despina Anagnostou, Savvas Vlachos… in Systematic Reviews (2019)

Article

Is the inflammasome a potential therapeutic target in renal disease?

The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cyt...

Clare M Turner, Nishkantha Arulkumaran, Mervyn Singer, Robert J Unwin… in BMC Nephrology (2014)

Article

Clinical review: Goal-directed therapy-what is the evidence in surgical patients? The effect on different risk groups

Patients with limited cardiac reserve are less likely to survive and develop more complications following major surgery. By augmenting oxygen delivery index (DO₂I) with a combination of intravenous fluids and ino...

Maurizio Cecconi, Carlos Corredor, Nishkantha Arulkumaran, Gihan Abuella… in Critical Care (2013)

Article

Long- term outcome of paediatric patients with ANCA vasculitis

Primary systemic vasculitis presenting in childhood is an uncommon but serious condition. As these patients transfer to adult clinics for continuing care, defining long term outcomes with emphasis on disease a...

Nishkantha Arulkumaran, Susan Jawad, Stuart W Smith… in Pediatric Rheumatology (2011)

Article

Haemodialysis and peritoneal dialysis patients admitted to intensive care units

Hutchison and colleagues report a 10-year experience of dialysis patients admitted to intensive care units (ICUs) in the UK excluding Scotland. Their study is the largest published so far and raises issues of ...

Nishkantha Arulkumaran, John B Eastwood, Debasish Banerjee in Critical Care (2007)