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Article
Open AccessA comprehensive metabolite fingerprint of fibrostenosis in patients with Crohn’s disease
Intestinal fibrostenosis in patients with Crohn’s disease (CD) is a common and untreatable comorbidity that is notoriously difficult to monitor. We aimed to find metabolites associated with the presence of fib...
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Article
MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis
To investigate the value of magnetization transfer (MT) MRI and texture analysis (TA) of T2-weighted MR images (T2WI) in the assessment of intestinal fibrosis in a mouse model.
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Article
Publisher Correction: Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis
Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of subclinical gut inflammation in...
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Article
Open AccessIBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are p...
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Article
Open AccessButyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity
The management of the dysbiosed gut microbiota in inflammatory bowel diseases (IBD) is gaining more attention as a novel target to control this disease. Probiotic treatment with butyrate-producing bacteria has...
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Article
T84 monolayers are superior to Caco-2 as a model system of colonocytes
Colonic adenocarcinoma-derived Caco-2 and T84 epithelial cell lines are frequently used as in vitro model systems of functional epithelial barriers. Both are utilised interchangeably despite evidence that diff...
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Article
Open AccessDifferential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn’s disease/infectious colitis and healthy controls
Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a pro...
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Article
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
A meta-analysis of previous genome-wide association studies of Crohn’s disease and ulcerative colitis, the two most common forms of inflammatory bowel disease, with a combined total of more than 75,000 cases a...
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Intestinal metaplasia and colonization of endometriosis in a case of an appendiceal mucinous neoplasm
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Article
Intrarectal Nitric Oxide Administration Prevents Cellular Infiltration but Not Colonic Injury During Dextran Sodium Sulfate Colitis
During inflammation in the gastrointestinal tract, the production of nitric oxide (NO) is mediated by the mucosal conversion of l-arginine. Recently, it was shown that the gut microbiota can also produce NO.
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Article
Correction: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Nat. Genet. 43, 246–252 (2011); published online 6 February 2011; corrected after print 11 August 2011 In the version of this article initially published, an affiliation was missing for two authors, Maria Gazo...
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Article
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
John Rioux and colleagues report results of a large genome-wide association meta-analysis and follow-up study of ulcerative colitis. They identify 29 new risk loci for this inflammatory disease and show that m...
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Article
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
Michel Georges and colleagues perform high-throughput resequencing of 63 positional candidate genes identified through genome-wide association studies to search for rare coding variants influencing risk of Cro...
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Article
Open AccessDifferential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease
Immunological and genetic findings implicate Th17 effector cytokines in the pathogenesis of inflammatory bowel disease (IBD). Expression of Th17 pathway-associated genes is mainly studied in colonic disease. T...
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Article
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Miles Parkes and colleagues report results of a large genome-wide association meta-analysis and replication study for Crohn's disease. They identify 30 new susceptibility loci for this inflammatory bowel disea...
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Article
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Mark Daly and colleagues present results of a combined analysis of data from three recent genome-wide association studies for Crohn's disease, followed by replication in a large independent sample collection. ...
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Article
Outcome of acute nonvariceal gastrointestinal haemorrhage after nontherapeutic arteriography compared with embolization
In acute nonvariceal gastrointestinal (GI) bleeding, immediate arteriographic haemostasis is presently assumed to be a therapeutic advantage. This study assesses whether the risk of a delayed haemostasis, caus...
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Article
Aspects endoscopiques de la dysplasie du tractus gastro-intestinal
L’endoscopie traditionnelle est utilisée pour la détection, la surveillance et le traitement des lésions dysplasiques de l’œsophage et du côlon.
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Article
Pathologie inflammatoire de ľHéon terminal
