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Article
MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis
To investigate the value of magnetization transfer (MT) MRI and texture analysis (TA) of T2-weighted MR images (T2WI) in the assessment of intestinal fibrosis in a mouse model.
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Article
EUS-guided versus PTC-guided rendezvous in case of failed ERCP: a case–control study
Endoscopic ultrasound-guided rendezvous (EUS-RV) is a recently added alternative salvage technique to percutaneous transhepatic cholangiography rendezvous (PTC-RV) for achieving biliary cannulation in failed E...
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Article
Outcome of primary ERCP versus primary PTC for biliary drainage in malignant hilar biliary strictures: a systematic review and meta-analysis
Patients with malignant hilar biliary strictures can suffer from obstructive jaundice. Controversy remains on the optimal approach to obtain preoperative or palliative biliary drainage in these patients. A sys...
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Article
Lumen-apposing metal stents for approved and off-label indications: a single-centre experience
Lumen-apposing stents (LAMS) are approved to treat peripancreatic collections and for gallbladder and bile duct drainage. Over the last years, LAMS have also been used for off-label indications including gastr...
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Article
Unmet Needs in IBD: the Case of Fatigue
Fatigue is a highly prevalent but relatively ignored problem in IBD patients. It is one of the most burdensome symptoms to the patient with an important impact on the quality of life. Therefore, fatigue is a h...
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Article
Bleeding Lesion of the Small Bowel: an Extensive Update Leaving No Stone Unturned
Gastrointestinal bleeding originating from the small bowel (SB) poses a challenge to the treating gastroenterologist. Once diagnosed, management is not a walk in the park either. This review intends to summari...
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Article
Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD
Mucosal hypoxia is an integral component of IBD
Hypoxia-induced signalling by hypoxia-inducible factors and...
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Article
T84 monolayers are superior to Caco-2 as a model system of colonocytes
Colonic adenocarcinoma-derived Caco-2 and T84 epithelial cell lines are frequently used as in vitro model systems of functional epithelial barriers. Both are utilised interchangeably despite evidence that diff...
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Article
Erratum to: Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview
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Article
Incidence, Prevention and Management of Anti-Drug Antibodies Against Therapeutic Antibodies in Inflammatory Bowel Disease: A Practical Overview
The introduction of biologic therapy has revolutionized the treatment of inflammatory bowel disease (IBD). However, like all therapeutic proteins, monoclonal antibodies have immunogenic potential which is infl...
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Chapter
Biological Therapy of Crohn’s Disease: Natalizumab, Vedolizumab, and Anti-MadCAM
Intestinal inflammation is highly dependent on the recruitment of white blood cells out from the circulation to the mucosal immune system of the gut. Diapedesis and transmigration of activated lymphocytes to t...
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Article
Acute severe ulcerative colitis: from pathophysiology to clinical management
Ulcerative colitis is a common condition, resulting from a complex interplay between environmental, genetic and microbial factors, and dysregulated immune resp...
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Article
Heterogeneity in endoscopic treatment of Crohn’s disease-associated strictures: An international inflammatory bowel disease specialist survey
Crohn’s disease (CD) is frequently complicated by intestinal strictures, which are commonly treated by endoscopic balloon dilation (EBD). However, available data on this area of treatment is limited. The aim o...
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Article
Open AccessDifferential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn’s disease/infectious colitis and healthy controls
Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional program that, in the gut, promotes intestinal epithelial cell survival. PHD inhibitors have recently been suggested as a pro...
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Article
Intrarectal Nitric Oxide Administration Prevents Cellular Infiltration but Not Colonic Injury During Dextran Sodium Sulfate Colitis
During inflammation in the gastrointestinal tract, the production of nitric oxide (NO) is mediated by the mucosal conversion of l-arginine. Recently, it was shown that the gut microbiota can also produce NO.
