11 Result(s)
within
Charlotte Grootaert
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Article
Quercetin Mitigates Endothelial Activation in a Novel Intestinal-Endothelial-Monocyte/Macrophage Coculture Setup
Atherosclerosis initiation is associated with a pro-inflammatory state of the endothelium. Quercetin is a flavonoid abundantly present in plant-based foods, with a possible impact on cardiovascular health. In ...
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Reference Work Entry In depth
Microbiome Metabolic Potency Towards Plant Bioactives and Consequences for Health Effects
Plant-based bioactive molecules containing a (modified) hydrocarbon backbone may have diverse health-promoting effects, but because of large interindividual variability the cause-consequence relationship is di...
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Article
Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives
A small set of structurally different monocarbonyl curcuminoids was prepared and screened for cytotoxic activity. In particular, bis-3-methoxy-4-hydroxy- and bis-4-methoxyphenyl-substituted monocarbonyls were ...
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Living Reference Work Entry In depth
Microbiome Metabolic Potency Towards Plant Bioactives and Consequences for Health Effects
Plant-based bioactive molecules containing a (modified) hydrocarbon backbone may have diverse health-promoting effects, but because of large interindividual variability the cause-consequence relationship is di...
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Article
Protein hydrolysate from canned sardine and brewing by-products improves TNF-α-induced inflammation in an intestinal–endothelial co-culture cell model
The anti-inflammatory activity of sardine protein hydrolysates (SPH) obtained by hydrolysis with proteases from brewing yeast surplus was ascertained.
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Article
Cu isotope fractionation response to oxidative stress in a hepatic cell line studied using multi-collector ICP-mass spectrometry
Reactive oxygen species (ROS) are generated in biological processes involving electron transfer reactions and can act in a beneficial or deleterious way. When intracellular ROS levels exceed the cell’s anti-ox...
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Article
Open AccessButyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity
The management of the dysbiosed gut microbiota in inflammatory bowel diseases (IBD) is gaining more attention as a novel target to control this disease. Probiotic treatment with butyrate-producing bacteria has...
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Article
Open AccessMicrobial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?
Awareness of the impact of microbiota in both health and disease is growing. Using a new in vitro oral mucosa co-culture model, we recently showed a clear inhibition of epithelial wound healing in the presence...
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Article
Two- and three-dimensional quantitative structure–permeability relationship of flavonoids in Caco-2 cells using stepwise multiple linear regression (SMLR), partial least squares regression (PLSR), and pharmacophore (GALAHAD)-based comparative molecular similarity index analysis (COMSIA)
Limited oral bioavailability has hindered the widespread use of flavonoids as bioactive substances. Several studies have been performed to evaluate the transport characteristics of flavonoids in the intestine...
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Article
Development of an oral mucosa model to study host-microbiome interactions during wound healing
Crosstalk between the human host and its microbiota is reported to influence various diseases such as mucositis. Fundamental research in this area is however complicated by the time frame restrictions during w...
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Article
In vitro model to study the modulation of the mucin-adhered bacterial community
There is an upsurge of interest in gastro-intestinal microbiology to improve the balance between positive and negative commensals. Mucosal bacteria make closer contact with the host than luminal ones and can t...
