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Article
Laparoscopic liver resection for colorectal liver metastases: retrospective analysis of prognostic factors and oncological outcomes in a single-center cohort
Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resec...
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Article
Comment on: “Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project”
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Article
Open AccessImmunohistochemistry as a screening tool for NTRK gene fusions: results of a first Belgian ring trial
A Belgian ring trial for pan-TRK immunohistochemistry (IHC) staining was organised to harmonise pan-TRK IHC staining protocols and interpretation. As a reference method, the VENTANA pan-TRK Assay (clone EPR173...
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Article
Open AccessBlockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
Lymphatic malformations (LMs) are debilitating vascular anomalies presenting with large cysts (macrocystic) or lesions that infiltrate tissues (microcystic). Cellular mechanisms underlying LM pathology are poo...
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Chapter
Drug-Induced Colon Injury
Drug-induced injury of the colon is a relatively frequent though underestimated event. The histological manifestations are very variable and frequently mimic other disease entities with different etiologies. T...
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Chapter
Treatment-Related Conditions
A variety of conditions may develop as an adverse event or within the context of certain types of treatment such as endoscopic and surgical procedures, radio- and chemotherapy, and stem cell or solid organ tra...
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Article
Comparison of HER2 amplification status among breast cancer subgroups offers new insights in pathways of breast cancer progression
Although the prognostic and predictive significance of human epidermal growth factor receptor 2 (HER2) in invasive breast cancer is well established, its role in ductal carcinoma in situ (DCIS) remains unclear...
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Article
Frequency and pathogenesis of central liver nodules in Alagille syndrome patients
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Article
Response to letter to the editor by Dr. Villanacci: toward optimal processing of endoscopic submucosal dissection specimens
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Article
Endoscopic submucosal dissection specimens in early colorectal cancer: lateral margins, macroscopic techniques, and possible pitfalls
Endoscopic submucosal dissection (ESD) allows en-bloc resection of superficial gastrointestinal tumors, providing specimens on which lateral margin analysis can be performed reliably. Positive lateral margins ...
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Article
What kind of prostate cancers do we miss on multiparametric magnetic resonance imaging?
To analyse the characteristics of prostate cancers (PrCa) detected following negative multiparametric magnetic resonance imaging (mpMRI).
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Article
Open AccessPlacental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisat...
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Article
Prognostic value of tumor shrinkage versus fragmentation following radiochemotherapy and surgery for rectal cancer
Most patients with rectal cancer receive neoadjuvant radiochemotherapy (RCT), causing a variable decrease in tumor mass. We evaluated the prognostic impact of pathologic parameters reflecting tumor response to...
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Article
Open AccessModulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy
Functional disturbances of the endoplasmic reticulum (ER) lead to activation of the unfolded protein response (UPR), which is involved in the consecutive steps of carcinogenesis. In human hepatocellular carcin...
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Article
Histopathological characterization of ductal carcinoma in situ (DCIS) of the breast according to HER2 amplification status and molecular subtype
This study aimed to characterize ductal carcinoma in situ (DCIS) according to human epidermal growth factor receptor 2 (HER2) amplification status and molecular subtype. In addition, we performed a detailed HE...
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Article
Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma
We studied a series of spindle cell lipomas arising in atypical sites and showing unusual morphologic features (which we called atypical spindle cell lipoma) to assess if these lesions have the same chromosoma...
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Article
Open AccessMolecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice
Chimeric mice with humanized livers represent a promising tool for infections with Plasmodium falciparum to evaluate novel methods for prevention and treatment of pre-erythrocytic stages. Adequate assessment of h...
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Article
Intestinal metaplasia and colonization of endometriosis in a case of an appendiceal mucinous neoplasm
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Article
MDM2 gene amplification and protein expressions in colon carcinoma: is targeting MDM2 a new therapeutic option?
The aim of this study was to investigate murine double minute-2 (MDM2) gene copy number changes in colon carcinoma and to correlate these findings with an immunohistochemical analysis of MDM2 protein expressio...
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Article
Severe Drug-induced Liver Injury Associated with Prolonged Use of Linezolid
This study aims to describe a patient develo** concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver ...
