4 Result(s)
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Article
Open AccessClinical landscape of macrophage-reprogramming cancer immunotherapies
Tumour-associated macrophages (TAMs) sustain a tumour-supporting and immunosuppressive milieu and therefore aggravate cancer prognosis. To modify TAM behaviour and unlock their anti-tumoural potential, novel T...
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Article
Open AccessVascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation
Although the development of hematopoietic stem cells (HSC) has been studied in great detail, their heterogeneity and relationships to different cell lineages remain incompletely understood. Moreover, the role ...
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Article
Open AccessNew tools to prevent cancer growth and spread: a ‘Clever’ approach
Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes and macrophages. Its role in cancer...
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Article
Regulation of CD73 in the development of lower limb atherosclerosis
Atherosclerosis is an inflammatory process of the arterial wall. CD73 (also known as ecto-5′-nucleotidase) is a key regulator of cell signaling in response to inflammation and hypoxia, and may be important in ...
