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Article
Open AccessRight atrial and ventricular strain detects subclinical changes in right ventricular function in precapillary pulmonary hypertension
Right ventricular (RV) ejection fraction (EF) by cardiac magnetic resonance (CMR) correlates to outcome in precapillary pulmonary hypertension (pPH) patients, but is insensitive to early changes. Strain might ...
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Article
Open AccessIntestinal hypomotility in systemic sclerosis: a histological study into the sequence of events
The pathogenesis of intestinal involvement in systemic sclerosis (SSc) is thought to be a sequential process (vascular, neuronal, and consecutive muscular impairment), but understanding of the underlying histo...
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How to Assess a Patient for HSCT
Treatment of early diffuse cutaneous systemic sclerosis (dcSSc) patients can be challenging especially when organ involvement is present. Comprehensive screening is therefore necessary to determine the nature ...
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Article
Open AccessTGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?
The pathophysiology of systemic sclerosis (SSc) is closely linked to overactive TGFβ signaling. TGFβ is produced and circulates in latent form, making its activation crucial for signaling. This activation can ...
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Article
Open AccessIntravenous cyclophosphamide pulse therapy in interstitial lung disease associated with systemic sclerosis in a retrospective open-label study: influence of the extent of inflammation on pulmonary function
Interstitial lung disease (ILD) is the primary cause of death in patients with systemic sclerosis (SSc). It is thought that chronic inflammation is a key component in SSc-ILD. Treatment, such as cyclophosphami...
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Article
Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis
There is increasing evidence that gene copy number (CN) variation influences clinical phenotype. The low-affinity Fc receptor 3B (FCGR3B) located in the FCGR gene cluster is a CN polymorphic gene involved in the ...
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Article
The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis
Regulatory T cells (Tregs) are crucial in the maintenance of the immune tolerance and seem to have an important role in systemic sclerosis (SSc). The interleukin 2 receptor α (IL2RA) is an important Treg marker, ...
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Article
Open AccessSkewed X-chromosomal inactivation impacts T regulatory cell function in systemic sclerosis
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Article
Open AccessVariants of PBEF predispose to systemic sclerosis and pulmonary arterial hypertension development
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Article
Open AccessIdentification of novel genetic markers associated with the clinical phenotypes of systemic sclerosis through a genome wide association strategy
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Article
Open AccessA replication study confirms the association of TNFSF4 (OX40L) polymorphisms with Systemic Sclerosis in a large European cohort
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Article
Open AccessPolymorphisms in the interleukin 4, interleukin 13 and corresponding receptor genes are not associated with Systemic Sclerosis and do not influence gene expression
