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Chapter and Conference Paper
Involvement of ICE-Like Proteases in Gemcitabine-Induced Programmed Cell Death
Activation of ICE-like-protease cascade is a crucial step in Fas/APO-1 (CD95) induced apoptosis in different cell lines. Here we determined the role of interleukin-1 ß-converting enzyme (ICE) and CPP32/YAMA in...
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Article
Increases of sICAM-1 during neutropenic pneumonia in leukemic patients
Aggressive chemotherapy of leukemia increases the risk of severe infections during treatment-induced myelosuppression. However, the assessment of an infectious origin of neutropenic fever is often difficult. L...
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Chapter and Conference Paper
Incidence and Severity of Amphotericin B-induced Acute Toxicity in Leukemic Patients After Treatment with Three Different Formulations (Amphotericin B, AmBisome and Amphotericin B/lntralipid) — A Pilot Study
Intravenous amphotericin B (AmB) is the most potent drug for treatment of systemic fungal infections in leukemic patients. However, use of this drug is often limited by renal side effects and acute toxicity (f...
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Article
Neutrophilic dermal infiltrates in granulocytopenic patients with acute leukemia
Acute febrile neutrophilic dermatosis (AFND, Sweet's syndrome) is clinically characterized by fever, neutrophilic leukocytosis, and tender dermal plaques. Histological examination typically reveals infiltratio...
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Article
Pulmonary toxicity during infusion of liposomal amphotericin B in two patients with acute leukemia
Pulmonary toxicity with acute dyspnea occurred during infusion of a liposomal amphotericin B preparation (AmBisome) in two adult leukemic patients. The preparation was administered as a one hour infusion at a ...
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Chapter and Conference Paper
Regulation of Erythropoietin Production in Patients with Myelodysplastic Syndromes
Preleukemic syndromes or myelodysplastic syndromes (MDS) comprise a heterogeneous group of acquired bone marrow disorders, probably resulting from malignant transformation of a multipotent hematopoietic stem c...
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Article
Abstract
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Article
Granulocyte colony-stimulating factor (G-CSF) treatment in a neutropenic leukemia patient with diffuse interstitial pulmonary infiltrates
Adult respiratory distress syndrome (ARDS) in patients suffering from acute leukemia usually occurs during chemotherapy-induced neutropenia. In addition, intensified chemotherapy with high-dose cytosine arabin...
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Article
GM-CSF therapy and capillary-leak syndrome
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Chapter and Conference Paper
Influence of Infusion Time on the Acute Toxicity of Amphotericin B: Results of a Randomized Double-Blind Study
Despite the development of several new antifungal drugs, intravenous amphotericin B (amB) is still considered the drug of choice for the treatment of severe systemic fungal infections in immunocompromised pati...
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Article
Septicemia due toStreptococcus mitis in neutropenic patients with acute leukemia
Eight neutropenic patients with acute lymphocytic or nonlymphocytic leukemia had septicemia due to different strains ofStreptococcus mitis (St. mitis), a microorganism not commonly recognized as a special pathoge...
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Chapter and Conference Paper
Preliminary Results of Treatment with Itraconazole in Patients with Systemic Fungal Infections
Patients with acute leukemias undergo a high risk of lethal systemic fungal infections during prolonged periods of granulocytopenia. While amphotericin B is still the most effective antimycotic drug, its use i...
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Article
Prevention of amphotericin-B-induced nephrotoxicity by loading with sodium chloride: A report of 1291 days of treatment with amphotericin B without renal failure
An open, prospective study was performed to evaluate the clinical usefulness of sodium chloride loading for prevention of amphotericin-B-induced nephrotoxicity in 37 patients requiring 44 courses of amphoteric...