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Article
Open AccessLong-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment
Tyrosine kinase inhibitors represent today’s treatment of choice in chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as salvage therapy. This prospective ra...
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Article
Ultratrace voltammetric determination of DNA-bound platinum in patients after administration of oxaliplatin
Oxaliplatin, a novel diaminocyclohexane-platinum complex, is used for the treatment of metastatic colorectal cancer. The amount of DNA-adduct formation of this drug in white blood cells of patients is determin...
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Article
Primary non-Hodgkin's lymphoma of bone: three cases and a short review of the literature
Primary non-Hodgkin's lymphoma of bone (PLB) is a rare entity. We present three new cases and a review of the literature. If PLB is suspected radiologically, the diagnosis must be confirmed by open biopsy. His...
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Article
Hemoglobinopathy York [β146 (HC3) His⇒Pro]: first report of a family history
The rare hemoglobinopathies with abnormal oxygen binding are usually characterized by erythropoietin-mediated erythrocytosis. Bare et al. first described a hemoglobinopathy with mild erythrocytosis in a 22-ye...
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Article
Pseudomonas aeruginosa blepharoconjunctivitis during cytoreductive chemotherapy in a woman with acute lymphocytic leukemia
Patients undergoing chemotherapy regimens for hematologic malignancies are prone to develop unusual and potentially life-threatening infections during periods of leukopenia- induced immunosuppression. We repo...
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Article
Reply to Ø Bruserud: Increases of sICAM-1 in neutropenic fever
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Article
Increases of sICAM-1 during neutropenic pneumonia in leukemic patients
Aggressive chemotherapy of leukemia increases the risk of severe infections during treatment-induced myelosuppression. However, the assessment of an infectious origin of neutropenic fever is often difficult. L...
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Chapter and Conference Paper
Interferon Therapy of Essential Thrombocythemia and Polycythemia Vera
The chronic myeloproliferative disorders are clonal diseases of the hematopoietic stem cell. Polycythemia vera (PV) is characterized by extensive trilineage bone marrow hyperplasia, whereas in essential thromb...
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Chapter and Conference Paper
Incidence and Severity of Amphotericin B-induced Acute Toxicity in Leukemic Patients After Treatment with Three Different Formulations (Amphotericin B, AmBisome and Amphotericin B/lntralipid) — A Pilot Study
Intravenous amphotericin B (AmB) is the most potent drug for treatment of systemic fungal infections in leukemic patients. However, use of this drug is often limited by renal side effects and acute toxicity (f...
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Chapter and Conference Paper
Hämostasestörungen bei myeloproliferativen Erkrankungen
Myeloproliferative Erkrankungen beruhen auf einer Veränderung der Knochenmarkstammzelle mit konsekutiver Expansion der klonalen Hämatopoese in allen Zellreihen. Abgesehen von Patienten mit chronisch-myeloische...
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Article
Neutrophilic dermal infiltrates in granulocytopenic patients with acute leukemia
Acute febrile neutrophilic dermatosis (AFND, Sweet's syndrome) is clinically characterized by fever, neutrophilic leukocytosis, and tender dermal plaques. Histological examination typically reveals infiltratio...
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Article
Pulmonary toxicity during infusion of liposomal amphotericin B in two patients with acute leukemia
Pulmonary toxicity with acute dyspnea occurred during infusion of a liposomal amphotericin B preparation (AmBisome) in two adult leukemic patients. The preparation was administered as a one hour infusion at a ...
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Article
Abstract
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Article
Incidence and clinical risk factors for bleeding and thrombotic complications in myeloproliferative disorders
Bleeding and thrombosis are frequent complications in myeloproliferative disorders (MPD) and are associated with severe organ damage and a high mortality. Elevated platelet count, elevated hematocrit, and pati...
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Article
Influence of splenectomy on platelet morphometry and function
Functional and morphometric platelet abnormalities may be influenced by splenectomy and thus contribute to postoperative thrombohaemorrhagic complications, especially in patients with splenomegaly and/or plate...
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Article
Platelet volume parameters as a diagnostic tool: The influence of anticoagulation and storage conditions on platelet impedance volume
Rapid progress has been made in the design of aperture impedance cell counters, and parameters such as mean platelet volume and platelet distribution width have become routinely available to most physicians. P...
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Article
Book reviews
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Article
Polychemotherapy of acute myelogenous leukemia in a patient with acute intermittent porphyria
The safety of drugs in hepatic porphyrias has largely been established by clinical experience, which is very limited in the case of antineoplastic agents. We administered three cycles of polychemotherapy consi...
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Article
Thrombotic and hemorrhagic tendency in patients with malignant disease
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Article
Inhibition of platelet thrombus formation by chlorpromazine acting to diminish haemolysis
There is increasing evidence1 that the sudden, unpredictable event initiating myocardial infarction is Assuring of an atherosclerotic plaque. The resulting haemorrhage into the arterial wall produces obstructive ...
