-
Article
Open AccessThe use of information technology to improve interdisciplinary communication during infectious diseases ward rounds on the paediatric intensive care unit
Prospective audit with feedback during infectious diseases ward rounds (IDWR) is a common antimicrobial stewardship (AMS) practice on the Paediatric Intensive Care Unit (PICU). These interdisciplinary meetings...
-
Article
Selective decontamination of the digestive tract: it’s all in your mind!
-
Article
Open AccessFerroptosis and pyroptosis signatures in critical COVID-19 patients
Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from severe multiple organ dysfunction with underlying widespread cell death. Ferroptosis and pyroptosis are two detriment...
-
Article
Selective digestive decontamination - Pro
-
Article
Open AccessPathogen-based target attainment of optimized continuous infusion dosing regimens of piperacillin-tazobactam and meropenem in surgical ICU patients: a prospective single center observational study
Several studies have indicated that commonly used piperacillin-tazobactam (TZP) and meropenem (MEM) dosing regimens lead to suboptimal plasma concentrations for a range of pharmacokinetic/pharmacodynamic (PK/P...
-
Article
Open AccessIn-hospital antibiotic use for severe chronic obstructive pulmonary disease exacerbations: a retrospective observational study
The use of antibiotics in mild to severe acute exacerbations of chronic obstructive pulmonary disease (COPD) remains controversial.
-
Article
Open AccessAdult essential extracorporeal membrane oxygenation (ECMO) skills for use in an e-learning program for ICU physicians, nurses and perfusionists: a consensus by a modified Delphi questionnaire
Education in ECMO starts with basic theory and physiology. For this type of training, self-assessment e-learning modules may be beneficial. The aim of this study was to generate consensus on essential ECMO ski...
-
Article
Open AccessEfficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with COVID-19: an open-label randomized controlled trial
The efficacy and safety of complement inhibition in COVID-19 patients is unclear.
-
Article
Open AccessCharacteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition: an analysis of real-time collected data
Baseline characteristics and disease severity of patients with septic shock according to the new Sepsis-3 definition may differ from patients that only comply with the Sepsis-2 definition. We conducted a retro...
-
Article
Open AccessTaskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis
Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Diagnosis and management of COVID-19 assoc...
-
Article
Open AccessOutcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients
Whether Intensive Care Unit (ICU) clinicians display unconscious bias towards cancer patients is unknown. The aim of this study was to compare the outcomes of critically ill patients with and without perceptio...
-
Article
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial
Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduce...
-
Article
Adult-onset congenital central hypoventilation syndrome due to PHOX2B mutation
Central hypoventilation in adult patients is a rare life-threatening condition characterised by the loss of automatic breathing, more pronounced during sleep. In most cases, it is secondary to a brainstem lesi...
-
Article
Open AccessTriage policy of severe Covid-19 patients: what to do now?
-
Article
Open AccessConceptions of the pathophysiology of happy hypoxemia in COVID-19
In their letter-to-the-editor entitled “Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19”, Tobin et al. (Respir Res 21:249, 2020) debated our views on happy hypo...
-
Article
Optimizing the Use of Antibiotic Agents in the Pediatric Intensive Care Unit: A Narrative Review
Antibiotics are one of the most prescribed drug classes in the pediatric intensive care unit, yet the incidence of inappropriate antibiotic prescribing remains high in critically ill children. Optimizing the u...
-
Article
Open AccessHaemoptysis as the first presentation of COVID-19: a case report
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic that profoundly challenges healthcare systems all over the world. Fever, ...
-
Article
Open AccessReview of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion
Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU). Classification of patients with influenza-associated pulmonary aspergillosis (IAP...
-
Article
Open AccessThe pathophysiology of ‘happy’ hypoxemia in COVID-19
The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet wi...
-
Article
Open AccessAntimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study
The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 fo...
