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Article
Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9
Aging contributes significantly to cardiovascular diseases and cardiac dysfunction, leading to the upregulation of matrix metalloproteinase-9 (MMP-9) in the heart and a significant decrease in hydrogen sulfide (H
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Article
2023: Weather and Climate Extremes Hitting the Globe with Emerging Features
Globally, 2023 was the warmest observed year on record since at least 1850 and, according to proxy evidence, possibly of the past 100 000 years. As in recent years, the record warmth has again been accompanied...
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Article
Open AccessEstablishment of a prognostic nomogram for elderly patients with limited-stage small cell lung cancer receiving radiotherapy
The present study explored the risk factors associated with radiotherapy in seniors diagnosed with limited-stage small cell lung cancer (LS-SCLC) to construct and validate a prognostic nomogram. The study retr...
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Article
Open AccessExtreme dry advection dominates the record-breaking Yangtze River heatwave in midsummer of 2022
The Yangtze River Valley (YRV) experienced an unprecedented heatwave in midsummer of 2022. Still, the detailed physical processes involved in the influence of abnormal large-scale atmospheric circulation on th...
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Article
Distribution assessment of soil erosion with revised RUSLE model in Tianshan Mountains
Soil degradation caused by soil erosion is one of the world’s most critical environmental issues. Soil erosion in the Tianshan Mountains has caused various environmental problems in the surrounding areas. This...
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Article
A role of NR4A2 in Graves’ disease: regulation of Th17/Treg
This study aimed to explore the molecular pathogenesis of Graves’ disease (GD).
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Article
Preface to the Special Issue on Causes, Impacts, and Predictability of Droughts for the Past, Present, and Future
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Article
Assessing the Performance of CMIP6 Models in Simulating Droughts across Global Drylands
Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However, reasonable drought simulations have remained a challenge, and the related performances of...
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Article
Open AccessMaternal Height Is an Independent Risk of Adverse Outcomes in Women with Gestational Diabetes Mellitus
Maternal height has been shown to be associated with adverse outcomes in women with gestational diabetes mellitus (GDM). The aim of this study is to evaluate the association between maternal height and adverse...
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Article
Open AccessDecision Impact Analysis to Measure the Influence of Molecular Signature Response Classifier Testing on Treatment Selection in Rheumatoid Arthritis
Clinical guidelines offer little guidance for treatment selection following inadequate response to conventional synthetic disease-modifying antirheumatic drug (csDMARD) in rheumatoid arthritis (RA). A molecula...
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Article
Intervention with extracellular matrix metalloproteinase inducer in osteoclasts attenuates periodontitis-induced bone resorption
Extracellular matrix metalloproteinase inducer (EMMPRIN) plays critical roles in the regulation of inflammation and bone metabolism. The roles of EMMPRIN signaling in osteoclasts are worthy of deep study. The ...
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Chapter
Casts
Casts are common components found in urine, distinguishable through microscopic examination or staining. The types and quantities of casts can be quantitatively reported, offering a precise foundation for clin...
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Article
Open AccessAuthor Correction: Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers
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Article
Open AccessHOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism
Cancer metabolism has emerged as a major target for cancer therapy, while the state of mitochondrial drugs has remained largely unexplored, partly due to an inadequate understanding of various mitochondrial fu...
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Article
Low-Dose Hexavalent Chromium Exposure Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Rat Liver
This study investigated the toxic effects of low-dose hexavalent chromium (Cr(VI)) on rat liver. Male specific pathogen-free (SPF) Sprague–Dawley (SD) rats (4–5 weeks of age) were randomly divided into groups:...
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Article
Open AccessThe association between metabolic dysfunction-associated steatotic liver disease, cardiovascular and cerebrovascular diseases and the thickness of carotid plaque
The relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and atherosclerosis has been controversial, which has become a hit of recent research. The study aimed to explore the a...
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Article
Open AccessReversed asymmetric warming of sub-diurnal temperature over land during recent decades
In the latter half of the twentieth century, a significant climate phenomenon “diurnal asymmetric warming” emerged, wherein global land surface temperatures increased more rapidly during the night than during ...
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Article
Understanding and Attribution of Extreme Heat and Drought Events in 2022: Current Situation and Future Challenges
Extreme weather events and their consequential impacts have been a key feature of the climate in recent years in many parts of the world, with many partly attributed to ongoing global-scale warming. The past y...
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Article
Open AccessEfficacy and Safety of Dupilumab in Older Patients (Aged 80 Years and Above) with Atopic Dermatitis: A Prospective Study
Atopic dermatitis presents unique challenges in the older population owing to age-related changes in skin barrier function and immune regulation. However, there is limited evidence on the efficacy and safety o...
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Article
Open AccessPreparation and anti-triple-negative breast cancer cell effect of a nanoparticle for the codelivery of paclitaxel and gemcitabine
Amphiphilic polymers (HA-ANI) were prepared by grafting hyaluronic acid (HA) and 6-(2-nitroimidazole)hexylamine (ANI) and then self-assemble in water to form nanoparticles (NPs) that could be loaded with pacli...
