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Article
A role of NR4A2 in Graves’ disease: regulation of Th17/Treg
This study aimed to explore the molecular pathogenesis of Graves’ disease (GD).
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Article
LncRNA FENDRR promotes apoptosis of Leydig cells in late-onset hypogonadism by facilitating the degradation of Nrf2
This study aimed to investigate the role of lncRNA FENDRR in apoptosis of Leydig cells and the further mechanism. The apoptosis of Leydig cells (TM3 cell line) was induced by H2O2-treatment and detected by flow c...
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Article
Open AccessExpansion of inflammatory monocytes in periphery and infiltrated into thyroid tissue in Graves’ disease
Monocytes are important mediators of immune system and are reported to be altered in autoimmune disorders. Little is known about the pathological role of monocytes in Graves’ disease (GD). Thus, we investigate...
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Article
Open AccessSerum and thyroid tissue level of let-7b and their correlation with TRAb in Graves’ disease
Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlap** in different cells and can be secreted to circulation. We chose miRNAs ...
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Article
Open AccessCorrection: Corrigendum: The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing
Nature Communications 8: Article number:15533 (2017); Published 5 June 2017; Updated 4 July 2017 The original version of this Article contained an error in the formatting of the author name Yang Shu, which was...
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Article
Open AccessThe genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing
The genomic alterations for benign thyroid nodule, especially adenomatoid nodule, one of the most common types of hyperplasia lesion, are ill-studied. Here, we show whole-exome sequencing and/or transcriptome ...
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Article
Increased chemokine (C–C motif) ligand 21 expression and its correlation with osteopontin in Graves’ disease
Graves’ disease (GD) is a chronic autoimmune process characterized by the production of auto-antibodies that presumably consequent to the lymphocytic infiltrates in the thyroid. Chemokine (C–C motif) ligand 21...
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Article
Circulating microRNA predicts insensitivity to glucocorticoid therapy in Graves’ ophthalmopathy
Glucocorticoid (GC) insensitivity occurs commonly in Graves’ ophthalmopathy (GO), and GC therapy is associated with major adverse effects. A reliable and easily accessible biomarker is required to predict the ...
