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Article
Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing
The continued development of clustered regularly interspaced short palindromic repeats (CRISPR) technology has the potential to greatly impact clinical medicine, particularly for disease diagnosis and treatmen...
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Article
A modular approach to enhancing cell membrane-coated nanoparticle functionality using genetic engineering
Since their initial development, cell membrane-coated nanoparticles (CNPs) have become increasingly popular in the biomedical field. Despite their inherent versatility and ability to enable complex biological ...
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Article
Biohybrid nanoparticles for treating arthritis
A biohybrid nanoparticle formulation effectively treats rheumatoid arthritis by concurrently providing symptom relief and restoring proper immune function.
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Article
Towards multifunctional robotic pills
Robotic pills leverage the advantages of oral pharmaceutical formulations—in particular, convenient encapsulation, high loading capacity, ease of manufacturing and high patient compliance—as well as the multif...
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Article
Inhalable mRNA nanoparticles
A large-scale screening identifies an inhalable polymer nanoparticle formulation that safely and effectively delivers therapeutic mRNA molecules to the lungs of several animal species.
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Article
Targeting drugs to tumours using cell membrane-coated nanoparticles
Traditional cancer therapeutics, such as chemotherapies, are often limited by their non-specific nature, causing harm to non-malignant tissues. Over the past several decades, nanomedicine researchers have soug...
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Article
Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia
Bioinspired microrobots capable of actively moving in biological fluids have attracted considerable attention for biomedical applications because of their unique dynamic features that are otherwise difficult t...
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Article
Open AccessAcute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy
Cancer vaccines are promising treatments to prevent relapse after chemotherapy in acute myeloid leukemia (AML) patients, particularly for those who cannot tolerate intensive consolidation therapies. Here, we r...
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Article
Three-dimensional transistor arrays for intra- and inter-cellular recording
Electrical impulse generation and its conduction within cells or cellular networks are the cornerstone of electrophysiology. However, the advancement of the field is limited by sensing accuracy and the scalabi...
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Article
Open AccessLure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
Acute pancreatitis is a disease associated with suffering and high lethality. Although the disease mechanism is unclear, phospholipase A2 (PLA2) produced by pancreatic acinar cells is a known pathogenic trigge...
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Article
Open AccessIntratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
Intratumoral immunotherapy is an emerging modality for the treatment of solid tumors. Toll-like receptor (TLR) agonists have shown promise for eliciting immune responses, but systemic administration often resu...
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Article
Nanomaterials arising amid antibiotic resistance
The rapid emergence of antibiotic resistance is recognized as a major public health threat. Nanomaterials have risen to tackle this problem through either improving the potency of existing antibiotics or gener...
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Article
Open AccessNatural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction
Compared to proteins, glycans, and lipids, much less is known about RNAs on the cell surface. We develop a series of technologies to test for any nuclear-encoded RNAs that are stably attached to the cell surfa...
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Chapter and Conference Paper
Fast Hyper-walk Gridded Convolution on Graph
The existing graph convolution methods usually suffer high computation burden, large memory requirement and intractable batch-process. In this paper, we propose a high-efficient hyper-walk gridded convolution ...
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Article
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Publisher Correction: On the issue of transparency and reproducibility in nanomedicine
An amendment to this paper has been published and can be accessed via a link at the top of the paper
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Article
On the issue of transparency and reproducibility in nanomedicine
Following our call to join in the discussion over the suitability of implementing a reporting checklist for bio–nano papers, the community responds.
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Article
Open AccessSelective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides
Despite significant advances in the treatment of human immunodeficiency virus type-1 (HIV) infection, antiretroviral therapy only suppresses viral replication but is unable to eliminate infection. Thus, discon...
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Article
Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis
Rheumatoid arthritis is a common chronic inflammatory disorder and a major cause of disability. Despite the progress made with recent clinical use of anti-cytokine biologics, the response rate of rheumatoid ar...
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Article
Monitoring of the central blood pressure waveform via a conformal ultrasonic device
Continuous monitoring of the central blood pressure waveform from deeply embedded vessels such as the carotid artery and jugular vein has clinical value for the prediction of all-cause cardiovascular mortality...
