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  1. Article

    Open Access

    Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics

    Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fatal genetic heart disease characterized by cardiac arrhythmias, in which fibrofatty deposition leads to heart failure, with no effective treatments...

    William H. Bradford, **g Zhang, Erika J. Gutierrez-Lara… in Nature Cardiovascular Research (2023)

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  2. No Access

    Article

    Three-dimensional transistor arrays for intra- and inter-cellular recording

    Electrical impulse generation and its conduction within cells or cellular networks are the cornerstone of electrophysiology. However, the advancement of the field is limited by sensing accuracy and the scalabi...

    Yue Gu, Chunfeng Wang, Namheon Kim, **gxin Zhang, Tsui Min Wang… in Nature Nanotechnology (2022)

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    Article

    Inhibition of L-type Ca2+ current in guinea pig ventricular myocytes by cisapride

    The effect of cisapride on L-type Ca2+ current (I Ca,L) was studied in guinea pig ventricular myocytes using a whole-cell voltage-clamp technique and a conventional action potential recording method. Myocytes wer...

    Chern-En Chiang MD, PhD, Tsui-Min Wang, Hsiang-Ning Luk in Journal of Biomedical Science (2004)

  4. No Access

    Article

    Genistein inhibits the inward rectifying potassium current in guinea pig ventricular myocytes

    Genistein is an isoflavone with potent inhibitory activity on protein tyrosine kinase. Previous studies have shown that genistein has additional effects, among which the direct blocking effects on various ioni...

    Chern-En Chiang Md, PhD, Hsiang-Ning Luk, Ling-Lan Chen… in Journal of Biomedical Science (2002)