13 Result(s)
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Lea M. D. Delbridge
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Article
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology
Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no other cardiac conditions but have a higher risk of develo** heart failure. Specific therapies to treat the diabetic heart...
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Article
Open AccessA novel small molecule inhibitor of human Drp1
Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes. Despite being the most wide...
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Article
Open AccessElevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro
Diabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct role for fructose involvement in diabetic heart p...
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Protocol
Mitochondrial Assays Using Cardiac Stem Cells
Ischemic heart disease is the leading cause of death worldwide. Stem cell therapy to repair and regenerate the infarcted myocardium is a promising approach to address this unmet medical need. However, the poor...
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Article
Open AccessCardiac troponins may be irreversibly modified by glycation: novel potential mechanisms of cardiac performance modulation
Dynamic movements of the cardiac troponin complex are an important component of the cardiac cycle. Whether cardiac troponins are subjected to irreversible advanced glycation end-product (AGE) modification is u...
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Article
Open AccessDiastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia
Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascular risk associated with diabetes is more marked for women, but an understanding ...
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Article
Myocardial stress and autophagy: mechanisms and potential therapies
Autophagic breakdown of cellular components is regulated by multiple signalling networks, including insulin and 5′-AMP-activated protein kinase pathways, and i...
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Article
Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium
Influences of adenosine 2A receptor (A2AR) activity on the cardiac transcriptome and genesis of endotoxemic myocarditis are unclear. We applied transcriptomic profiling (39 K Affymetrix arrays) to identify A2AR-s...
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Article
Open AccessMale and female hypertrophic rat cardiac myocyte functional responses to ischemic stress and β-adrenergic challenge are different
Cardiac hypertrophy is the most potent cardiovascular risk factor after age, and relative mortality risk linked with cardiac hypertrophy is greater in women. Ischemic heart disease is the most common form of c...
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Article
The role of CaMKII in diabetic heart dysfunction
Diabetes mellitus (DM) is an increasing epidemic that places a significant burden on health services worldwide. The incidence of heart failure (HF) is significantly higher in diabetic patients compared to non-...
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Article
Ageing-related cardiomyocyte functional decline is sex and angiotensin II dependent
Clinically, heart failure is an age-dependent pathological phenomenon and displays sex-specific characteristics. The renin-angiotensin system mediates cardiac pathology in heart failure. This study investigate...
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Article
Myocardial Gene Expression Associated with Genetic Cardiac Hypertrophy in the Absence of Hypertension
The hypertrophic heart rat (HHR) was derived from the spontaneously hypertensive rat of the Okamoto strain and develops cardiac hypertrophy in the absence of hypertension. The genetic basis of this hypertrophy...
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Article
Quantitative phase microscopy: a new tool for measurement of cell culture growth and confluency in situ
Quantitative phase microscopy (QPM) is a recently developed computational approach that provides quantitative phase measurements of specimen images obtained under bright-field conditions without phase- or inte...
