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Article
Open AccessAt the heart of mitochondrial quality control: many roads to the top
Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and s...
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Article
Open AccessMyocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury
Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important ...
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Article
Myocardial stress and autophagy: mechanisms and potential therapies
Autophagic breakdown of cellular components is regulated by multiple signalling networks, including insulin and 5′-AMP-activated protein kinase pathways, and i...
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Article
Open AccessParallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells
Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) and agonistic antibodies to death receptor 4 and 5 are promising candidates for cancer therapy due to their ability to induce apoptosis selective...
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Article
Open AccessThe cytoplasmic 60 kDa progesterone receptor isoform predominates in the human amniochorion and placenta at term
The mechanism that initiates human parturition has been proposed to be 'functional progesterone withdrawal' whereby the 116 kDa B-isoform of the progesterone receptor (PR-B) switches in favour of the 94 kDa A-...
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Article
Relationship between Antenatal Inflammation and Antenatal Infection Identified by Detection of Microbial Genes by Polymerase Chain Reaction
Although antenatal infection is thought to play an important role in the pathogenesis of preterm labor and neonatal diseases, the exact mechanisms are largely unknown. We sought to clarify the relationship bet...
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Article
Longitudinal Study of Fetal Body Movements: Nomograms, Intrafetal Consistency, and Relationship with Episodes of Heart Rate Patterns A and B
Our objective was to investigate the longitudinal development of incidence parameters of fetal body movements to define normal reference ranges, to relate them to episodes of fetal heart rate patterns A and B,...
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Chapter and Conference Paper
Self-Organizing Hierarchical Cluster Timestamps
Distributed-system observation tools require an efficient data structure to store and query the partial-order of execution. Such data structures typically use vector timestamps to efficiently answer precedence...
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Chapter and Conference Paper
Scalable Visualization of Event Data
Monitoring large distributed systems often results in massive quantities of data that must be analyzed in order to yield useful information about the system. This paper describes a task-oriented approach to ex...
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Article
Vector time and causality among abstract events in distributed computations
An important problem in analyzing distributed computations is the amount of information. In event-based models, even for simple applications, the number of events is large and the causal structure is complex....
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Article
Changes in brain amine levels associated with the morphological and behavioural development of the worker honeybee
Changes in biogenic amine levels associated with the morphological and behavioural development of the worker honeybee are examined.
