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Article
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology
Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no other cardiac conditions but have a higher risk of develo** heart failure. Specific therapies to treat the diabetic heart...
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Article
Open AccessLong non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle
Mitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such as cellular bioenergetics and response to stress. In the metabolicall...
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Article
Open AccessIs vascular insulin resistance an early step in diet-induced whole-body insulin resistance?
There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This proc...
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Article
Open AccessSkeletal muscle cell-specific differences in type 2 diabetes
Major stores of glucose are found as glycogen in skeletal muscle and liver. Skeletal muscle is a heterogenous tissue, with cellular metabolic and contractile distinctions dependent on whether the cell (fibre) ...
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Article
Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes
Microvascular blood flow (MBF) increases in skeletal muscle postprandially to aid in glucose delivery and uptake in muscle. This vascular action is impaired in individuals who are obese or have type 2 diabetes...
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Article
Open AccessTotal testosterone is not associated with lean mass or handgrip strength in pre-menopausal females
The aim of this study was to examine the relationship between endogenous testosterone concentrations and lean mass and handgrip strength in healthy, pre-menopausal females. Testosterone has been positively ass...
