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    Article

    Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification

    Neoantigen prediction from clinical samples is improved using a neural network model trained on a large HLA peptide and genomic tumor dataset.

    Brendan Bulik-Sullivan, Jennifer Busby, Christine D Palmer… in Nature Biotechnology (2019)

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    Article

    An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

    KDM5 histone demethylases promote the survival of drug-tolerant persister (DTP) cells in certain cancers. CPI-455, a chemical probe specific for KDM5, elevates cellular H3K4 methylation levels and reduces DTP ...

    Maia Vinogradova, Victor S Gehling, Amy Gustafson, Shilpi Arora… in Nature Chemical Biology (2016)