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  1. Article

    Open Access

    Relaxed targeting rules help PIWI proteins silence transposons

    In eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct AGO-clade Argonaute proteins to regulate gene expression and defend the genome against external threats. Only animals make ...

    Ildar Gainetdinov, Joel Vega-Badillo, Katharine Cecchini, Ayca Bagci… in Nature (2023)

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  2. Article

    Open Access

    Improved cytosine base editors generated from TadA variants

    Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally occurring cytidine deaminase, and an inhibitor of uraci...

    Dieter K. Lam, Patricia R. Feliciano, Amena Arif, Tanggis Bohnuud… in Nature Biotechnology (2023)

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  3. Article

    Open Access

    GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins

    Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins have diverse biological functions and many retain their ancestral endoribonuclease activity,...

    Amena Arif, Shannon Bailey, Natsuko Izumi, Todd A. Anzelon, Deniz M. Ozata… in Nature (2022)

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  4. No Access

    Article

    The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility

    Pachytene PIWI-interacting RNAs (piRNAs), which comprise >80% of small RNAs in the adult mouse testis, have been proposed to bind and regulate target RNAs like microRNAs, cleave targets like short interfering ...

    Pei-Hsuan Wu, Yu Fu, Katharine Cecchini, Deniz M. Özata, Amena Arif… in Nature Genetics (2020)